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Associations between Two Polymorphisms (FokI and BsmI) of Vitamin D Receptor Gene and Type 1 Diabetes Mellitus in Asian Population: A Meta-Analysis

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  • Guofeng Wang
  • Qingqing Zhang
  • Ning Xu
  • Kuanfeng Xu
  • Jian Wang
  • Wei He
  • Tao Yang

Abstract

Background: Vitamin D receptor (VDR) gene polymorphisms are possibly involved in the development of type 1 diabetes mellitus (T1DM). However, the results to date have been inconclusive. We performed a meta-analysis to examine the association between 2 polymorphisms (FokI and BsmI) of the VDR gene and T1DM in the Asian population. Methods: Literature was retrieved from PubMed, Web of Science, CBM, Embase and Chinese databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random or fixed effect model. Results: In total, 20 papers (BsmI: 13 studies; FokI: 13 studies) were included. In contrast to the FokI polymorphism, the BsmI polymorphism was associated with an increased risk of T1DM in the Asian population (OR = 1.47, 95% CI = 1.13–1.91, P = 0.004 for B vs. b). Upon stratification by regional geography, an increased risk of T1DM in association with the BsmI polymorphism was observed in the East Asian population (OR = 1.97, 95% CI = 1.38–2.83, P

Suggested Citation

  • Guofeng Wang & Qingqing Zhang & Ning Xu & Kuanfeng Xu & Jian Wang & Wei He & Tao Yang, 2014. "Associations between Two Polymorphisms (FokI and BsmI) of Vitamin D Receptor Gene and Type 1 Diabetes Mellitus in Asian Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-7, March.
    • Handle: RePEc:plo:pone00:0089325
    DOI: 10.1371/journal.pone.0089325
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    Cited by:

    1. Natalia Gomez Lopera & Alejandra Rodriguez & Martin Toro & Maria Victoria Lopera & Alejandra Velez & Juan Manuel Alfaro & Nicolas Pineda Trujillo, 2018. "VDR Gene Haplotypes Associate with Type 1 Diabetes and Suggest Interaction with HLA, IL2RA and CTLA4 loci in Colombian Families," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 6(3), pages 1-7, March.
    2. Natalia Gomez Lopera & Alejandra Rodriguez & Martin Toro & Maria Victoria Lopera & Alejandra Velez & Juan Manuel Alfaro & Nicolas Pineda Trujillo, 2018. "VDR Gene Haplotypes Associate with Type 1 Diabetes and Suggest Interaction with HLA, IL2RA and CTLA4 loci in Colombian Families," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 6(3), pages 42-48, March.

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