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Impaired Cerebral Autoregulation-A Common Neurovascular Pathway in Diabetes may Play a Critical Role in Diabetes-Related Alzheimers Disease

Author

Listed:
  • Shashank Shekhar

    (Department of Neurology, University of Mississippi Medical Center, USA
    Institute of Clinical Medicine, University of Turku, Finland)

  • Shaoxun Wang

    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA)

  • Paige N Mims

    (3Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA)

  • Ezekiel Gonzalez-Fernandez

    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA)

  • Chao Zhang

    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
    Department of Urology, Fudan University, China)

  • Xiaochen He

    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA)

  • Catherine Y Liu

    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA)

  • Wenshan Lv

    (Department of Pharmacology and Toxicology, University of Mississippi Medical Center, USA
    Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, China)

  • Yangang Wang

    (Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, China)

  • Juebin Huang

    (Department of Neurology, University of Mississippi Medical Center, USA)

  • Fan Fan

    (Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, China)

Abstract

Alzheimer’s disease (AD) is the leading cause of progressive degenerative dementia. The hallmark pathological features include beta amyloid deposition and neurofibrillary tangles. There has been astrong association of AD with Diabetes (DM) based on human studies and animal experiments. The hallmark features of AD seem to have an exaggerated presence in AD with DM, especially type 2 diabetes (T2D). In addition, insulin resistance is a common feature in both diseases and as such AD has been called type 3 diabetes. Furthermore, impairment of cerebral autoregulation has been reported in both animal and human diabetic subjects. Cerebral vascular impairment has also been implicated in the pathophysiology of AD. There is an urgent need to develop animal models of AD and DM to explore the neuropathological mechanisms of these disease and utilize such models to develop treatment strategies

Suggested Citation

  • Shashank Shekhar & Shaoxun Wang & Paige N Mims & Ezekiel Gonzalez-Fernandez & Chao Zhang & Xiaochen He & Catherine Y Liu & Wenshan Lv & Yangang Wang & Juebin Huang & Fan Fan, 2017. "Impaired Cerebral Autoregulation-A Common Neurovascular Pathway in Diabetes may Play a Critical Role in Diabetes-Related Alzheimers Disease," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 2(3), pages 40-45, June.
    • Handle: RePEc:adp:jcrdoj:v:2:y:2017:i:3:p:40-45
    DOI: 10.19080/CRDOJ.2017.02.555587
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    References listed on IDEAS

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    1. David Attwell & Alastair M. Buchan & Serge Charpak & Martin Lauritzen & Brian A. MacVicar & Eric A. Newman, 2010. "Glial and neuronal control of brain blood flow," Nature, Nature, vol. 468(7321), pages 232-243, November.
    Full references (including those not matched with items on IDEAS)

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    More about this item

    Keywords

    juniper publishers; diabetes journals; diabetes impact factor; endocrinology journal; endocrinology impact factor; endocrinology research journal; endocrinology research articles; diabetes open access journals; Obesity Journal; Diabetes & Obesity Journal;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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