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HematologicalDevelopment of Enpp1 Inhibitors as a Strategy to Activate Stimulator of Interferon Genes (STING) in Cancers and Other Diseases

Author

Listed:
  • Manas Sharma
  • Trason Thode
  • Alexis Weston

    (Brophy College Preparatory, USA)

  • Mohan R Kaadige

    (Applied Cancer Research and Drug Discovery, Translational Genomics Research Institute, USA)

Abstract

Ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1/NPP1) is a membrane-bound nucleotide metabolizing enzyme that is implicated in a variety of physiological and pathological conditions. Recently, ENPP1 was discovered as the dominant 2’3’-cGAMP hydrolyzing enzyme. 2’3’-cGAMP is the endogenous STING agonist, generated from breakdown of cytosolic DNA by cGAS. Hydrolysis resistant 2’3’-cGAMP’s have been demonstrated to be potent activators of STING-dependent innate immunity and these are currently undergoing clinical trials in cancer. Here we discuss ENPP1 as a potential therapeutic target for activation of STING-dependent innate immune response.

Suggested Citation

  • Manas Sharma & Trason Thode & Alexis Weston & Mohan R Kaadige, 2018. "HematologicalDevelopment of Enpp1 Inhibitors as a Strategy to Activate Stimulator of Interferon Genes (STING) in Cancers and Other Diseases," International Journal of Cell Science & Molecular Biology, Juniper Publishers Inc., vol. 5(1), pages 24-28, September.
    • Handle: RePEc:adp:ijcsmb:v:5:y:2018:i:1:p:24-28
    DOI: 10.19080/IJCSMB.2018.04.555655
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    References listed on IDEAS

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    1. Dara L. Burdette & Kathryn M. Monroe & Katia Sotelo-Troha & Jeff S. Iwig & Barbara Eckert & Mamoru Hyodo & Yoshihiro Hayakawa & Russell E. Vance, 2011. "STING is a direct innate immune sensor of cyclic di-GMP," Nature, Nature, vol. 478(7370), pages 515-518, October.
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