IDEAS home Printed from https://ideas.repec.org/a/adm/journl/v11y2022i7p1-8.html
   My bibliography  Save this article

Improvement of Piperine on the Disturbed Intestinal Flora and Leaky Gut in Obese Mice

Author

Listed:
  • Ruixin Hu
  • Ji Zhou
  • Guohui Jiang
  • Lixia Ji

Abstract

Disturbed intestinal flora and leaky gut play the key roles in the occurrence of obesity-induced diabetes. Piperine can reduce the metabolic inflammation in obese mice and delay the occurrence of diabetes, but the mechanism is not clear. We aim to explore the potential mechanism of piperine in terms of intestinal barrier integrity and flora composition. Here, the obese mice model was induced by feeding 60% high-fat diet, and the feces of each mice were collected for 16s analysis of intestinal flora after intragastric administration of piperine (15 mg/kg/d) for 8 weeks. We found that piperine treatment decreased the serum contents of LPS, TNF-α and FFA, inhibited the high expression of inflammation-related proteins (TLR4, IL-1 β and CD11C) and upregulated the permeability-related proteins (ZO-1 and occludin) of ileum. Piperine also adjusted the ratio of Firmicutes to Bacteroides, changed the diversity and community richness of intestinal flora and regulated the content of short-chain fatty acids. Taken together, piperine can inhibit the occurrence of intestinal leakage by improving the disturbance of intestinal flora and the intestinal barrier integrity in obese mice.

Suggested Citation

  • Ruixin Hu & Ji Zhou & Guohui Jiang & Lixia Ji, 2022. "Improvement of Piperine on the Disturbed Intestinal Flora and Leaky Gut in Obese Mice," International Journal of Sciences, Office ijSciences, vol. 11(07), pages 1-8, July.
    • Handle: RePEc:adm:journl:v:11:y:2022:i:7:p:1-8
    DOI: 10.18483/ijSci.2596
    as

    Download full text from publisher

    File URL: https://www.ijsciences.com/pub/article/2596
    Download Restriction: no
    File URL: https://www.ijsciences.com/pub/pdf/V112022072596.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.18483/ijSci.2596?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Andrew L. Kau & Philip P. Ahern & Nicholas W. Griffin & Andrew L. Goodman & Jeffrey I. Gordon, 2011. "Human nutrition, the gut microbiome and the immune system," Nature, Nature, vol. 474(7351), pages 327-336, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Wiese, Daniel & Rodriguez Escobar, Jeronimo & Hsu, Yohsiang & Kulathinal, Rob J. & Hayes-Conroy, Allison, 2018. "The fluidity of biosocial identity and the effects of place, space, and time," Social Science & Medicine, Elsevier, vol. 198(C), pages 46-52.
    2. Deng-Ho Yang & Jing-Yang Huang & Jeng-Yuan Chiou & James Cheng-Chung Wei, 2018. "Analysis of Socioeconomic Status in the Patients with Rheumatoid Arthritis," IJERPH, MDPI, vol. 15(6), pages 1-12, June.
    3. Shuai Zou & Jingpu Zhang & Zuping Zhang, 2017. "A novel approach for predicting microbe-disease associations by bi-random walk on the heterogeneous network," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-16, September.
    4. Darrouzet-Nardi, Amelia & Masters, William, 2015. "Nutrition smoothing: Can access to towns and cities protect children against poor health conditions at birth?," 2015 Conference, August 9-14, 2015, Milan, Italy 211558, International Association of Agricultural Economists.
    5. Xin He & Wenjing Wang & Zhenni Zhu & Jiajie Zang & Tong Liu & Yan Shi & Chen Fu, 2022. "Percent Body Fat-Related Disparities of Serum Ferritin on the Risk of Lipid Metabolism Abnormalities in Children and Adolescents," IJERPH, MDPI, vol. 19(23), pages 1-9, December.
    6. Kelvin Li & Monika Bihan & Shibu Yooseph & Barbara A Methé, 2012. "Analyses of the Microbial Diversity across the Human Microbiome," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-18, June.
    7. Kai Lun Chang & Paul C Ho, 2014. "Gas Chromatography Time-Of-Flight Mass Spectrometry (GC-TOF-MS)-Based Metabolomics for Comparison of Caffeinated and Decaffeinated Coffee and Its Implications for Alzheimer’s Disease," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-7, August.
    8. Coilín ÓhAiseadha & Gerry A. Quinn & Ronan Connolly & Awwad Wilson & Michael Connolly & Willie Soon & Paul Hynds, 2023. "Unintended Consequences of COVID-19 Non-Pharmaceutical Interventions (NPIs) for Population Health and Health Inequalities," IJERPH, MDPI, vol. 20(7), pages 1-40, March.
    9. Darrouzet-Nardi, Amelia & Masters, William A., 2014. "Market access and child nutrition in a conflict environment," 2014 Annual Meeting, July 27-29, 2014, Minneapolis, Minnesota 170286, Agricultural and Applied Economics Association.
    10. Ming Yang & Xiaoqiang Qi & Nan Li & Jussuf T. Kaifi & Shiyou Chen & Andrew A. Wheeler & Eric T. Kimchi & Aaron C. Ericsson & R. Scott Rector & Kevin F. Staveley-O’Carroll & Guangfu Li, 2023. "Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adm:journl:v:11:y:2022:i:7:p:1-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Staff ijSciences (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.