Marek’s Disease and Its Outbreak in Asia: Python-Based Approach for Detection of Marek’s Virus

Marek's disease is an infectious disease that manifests in tumors of the nervous system and organs in chickens. Computer programming languages have enough potential to detect various viral diseases. An effort has been made to detect and evaluate the intensity of viruses. Despite the widespread use of effective vaccines designed to halt its spread, recent data reveal that their efficacy is declining as a result of the virus's adaptability. We analyzed 53 reports documenting 157 viral strains in Asian countries during the last decade of Marek's disease outbreaks and correlated meq sequences. The visceral variety of Marek's disease is the most common (18 out of 28 investigations), although there may be other, unrecognized brain alterations as well. Most commonly, MD causes tumors in the liver (16 out of 26 studies), however, other organs such as the spleen, kidney, heart, gizzard, skin, gut, lung, and sciatic nerve have also been affected. Using amino acid alignment, we found numerous point alterations in 28 strains that may be associated with its virulence. More research is needed on the virulence of the Marek strain, as well as the structural modifications to the Meq protein, and we recommend that this research take place in disease-endemic areas.