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Precision Medicine: Implications for value chains and business models in life sciences

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  • Denicolai, Stefano
  • Previtali, Pietro

Abstract

Precision Medicine (PM) is expected to be one of the biggest revolutions of the upcoming years and not only in the healthcare industry. PM aims to prevent and treat disease on the basis of a person's unique genetic makeup, lifestyle habits, and environment. While the topic has attracted huge attention from scholars in the biomedical field of research, in contrast, literature in the field of business studies is almost absent. This in itself is surprising: this revolution implies a profound impact on the business models of companies and institutions as it pushes a new paradigm of sustainable development for healthcare and welfare systems at the global level. However, little is known about whether, to what extent, and in what direction these dynamics are impacting on the way organisations and value chains are managed, from research to care delivery. Our study addresses this gap: we discuss both theoretical arguments and empirical evidence from a multiple case study survey. Findings show that PM is a multi-faceted phenomenon grounded on novel forms of innovation eco-systems and bundled-based models. We reveal a dramatic shift in the value chain, which is moving upstream from recovery and surgery to prevention and monitoring.

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  • Denicolai, Stefano & Previtali, Pietro, 2020. "Precision Medicine: Implications for value chains and business models in life sciences," Technological Forecasting and Social Change, Elsevier, vol. 151(C).
    • Handle: RePEc:eee:tefoso:v:151:y:2020:i:c:s0040162519311023
    DOI: 10.1016/j.techfore.2019.119767
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    as
    1. Domingo Ribeiro-Soriano & Miguel-Ángel Galindo-Martín, 2012. "Government policies to support entrepreneurship," Entrepreneurship & Regional Development, Taylor & Francis Journals, vol. 24(9-10), pages 861-864, December.
    2. Andrew M. Jones & James Lomas & Nigel Rice, 2015. "Healthcare Cost Regressions: Going Beyond the Mean to Estimate the Full Distribution," Health Economics, John Wiley & Sons, Ltd., vol. 24(9), pages 1192-1212, September.
    3. Philip Anderson, 1999. "Perspective: Complexity Theory and Organization Science," Organization Science, INFORMS, vol. 10(3), pages 216-232, June.
    4. Antonella Zucchella & Pietro Previtali, 2019. "Circular business models for sustainable development: A “waste is food” restorative ecosystem," Business Strategy and the Environment, Wiley Blackwell, vol. 28(2), pages 274-285, February.
    5. Ron Adner & Rahul Kapoor, 2010. "Value creation in innovation ecosystems: how the structure of technological interdependence affects firm performance in new technology generations," Strategic Management Journal, Wiley Blackwell, vol. 31(3), pages 306-333, March.
    6. Gerard Harty & James Jarrett & Mireia Jofre-Bonet, 2018. "Consequences of Biomarker Analysis on the Cost-Effectiveness of Cetuximab in Combination with FOLFIRI as a First-Line Treatment of Metastatic Colorectal Cancer: Personalised Medicine at Work," Applied Health Economics and Health Policy, Springer, vol. 16(4), pages 515-525, August.
    7. Jerker Moodysson & Elena Zukauskaite, 2014. "Institutional Conditions and Innovation Systems: On the Impact of Regional Policy on Firms in Different Sectors," Regional Studies, Taylor & Francis Journals, vol. 48(1), pages 127-138, January.
    8. Philip Cooke, 2005. "Rational drug design, the knowledge value chain and bioscience megacentres," Cambridge Journal of Economics, Oxford University Press, vol. 29(3), pages 325-341, May.
    9. Guillaume Lamé & Oualid Jouini & Julie Stal-Le Cardinal, 2020. "Combining Soft Systems Methodology, Ethnographic Observation and Discrete-Event Simulation: A Case Study in Cancer Care," Post-Print hal-02095031, HAL.
    10. Ehrenhard, Michel & Kijl, Bjorn & Nieuwenhuis, Lambert, 2014. "Market adoption barriers of multi-stakeholder technology: Smart homes for the aging population," Technological Forecasting and Social Change, Elsevier, vol. 89(C), pages 306-315.
    11. Moors, Ellen H.M. & Kukk Fischer, Piret & Boon, Wouter P.C. & Schellen, Frank & Negro, Simona O., 2018. "Institutionalisation of markets: The case of personalised cancer medicine in the Netherlands," Technological Forecasting and Social Change, Elsevier, vol. 128(C), pages 133-143.
    12. María-Teresa Méndez-Picazo & Miguel-Ángel Galindo-Martín & Domingo Ribeiro-Soriano, 2012. "Governance, entrepreneurship and economic growth," Entrepreneurship & Regional Development, Taylor & Francis Journals, vol. 24(9-10), pages 865-877, December.
    13. Lee, DonHee, 2018. "Strategies for technology-driven service encounters for patient experience satisfaction in hospitals," Technological Forecasting and Social Change, Elsevier, vol. 137(C), pages 118-127.
    14. Petrakaki, Dimitra & Hilberg, Eva & Waring, Justin, 2018. "Between empowerment and self-discipline: Governing patients' conduct through technological self-care," Social Science & Medicine, Elsevier, vol. 213(C), pages 146-153.
    15. Periyasami Anbarasan & Sushil, 2018. "Stakeholder Engagement in Sustainable Enterprise: Evolving a Conceptual Framework, and a Case Study of ITC," Business Strategy and the Environment, Wiley Blackwell, vol. 27(3), pages 282-299, March.
    16. Nakamura, Hiroko & Suzuki, Shinji & Sakata, Ichiro & Kajikawa, Yuya, 2015. "Knowledge combination modeling: The measurement of knowledge similarity between different technological domains," Technological Forecasting and Social Change, Elsevier, vol. 94(C), pages 187-201.
    17. Gregory S. Zaric, 2016. "Cost Implications of Value-Based Pricing for Companion Diagnostic Tests in Precision Medicine," PharmacoEconomics, Springer, vol. 34(7), pages 635-644, July.
    18. Gastaldi, Luca & Pietrosi, Astrid & Lessanibahri, Sina & Paparella, Marco & Scaccianoce, Antonio & Provenzale, Giuseppe & Corso, Mariano & Gridelli, Bruno, 2018. "Measuring the maturity of business intelligence in healthcare: Supporting the development of a roadmap toward precision medicine within ISMETT hospital," Technological Forecasting and Social Change, Elsevier, vol. 128(C), pages 84-103.
    19. Shaw, Duncan R. & Allen, Tim, 2018. "Studying innovation ecosystems using ecology theory," Technological Forecasting and Social Change, Elsevier, vol. 136(C), pages 88-102.
    20. Callegaro, Aline Marian & Caten, Carla Schwengber ten & Tanure, Raffaela Leane Zenni & Buss, Amanda Sória & Echeveste, Márcia Elisa Soares & Jung, Carlos Fernando, 2016. "Managing requirements for the development of a novel elbow rehabilitation device," Technological Forecasting and Social Change, Elsevier, vol. 113(PB), pages 404-411.
    21. James Love-Koh & Alison Peel & Juan Carlos Rejon-Parrilla & Kate Ennis & Rosemary Lovett & Andrea Manca & Anastasia Chalkidou & Hannah Wood & Matthew Taylor, 2018. "The Future of Precision Medicine: Potential Impacts for Health Technology Assessment," PharmacoEconomics, Springer, vol. 36(12), pages 1439-1451, December.
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    8. Jin Sung Rha & Hong-Hee Lee, 2022. "Research trends in digital transformation in the service sector: a review based on network text analysis," Service Business, Springer;Pan-Pacific Business Association, vol. 16(1), pages 77-98, March.
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