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Rational drug design, the knowledge value chain and bioscience megacentres

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  • Philip Cooke

Abstract

This paper seeks to trace important shifts and cluster evolution in the healthcare industry. Its key aim is to examine the implications of the rise of science-based clusters for economic geography and related policies. A special focus is biosciences and the rise of 'biologics' more generally at the expense of fine chemistry in drug development. The old agglomerations of pharmacy are no longer leaders in knowledge exploration, as universities, research laboratories and medical schools take over research, they are beginning to lose prominence to dedicated biotechnology firms (DBFs) in knowledge examination, and retain their most important involvement as financiers and marketers of DBF exploitation knowledge. This has profound geographical as well as industry organisation equilibrium effects. Over-concentration of the bioscientific knowledge value chain has given rise to the new spatial policy practice of developing regional science strategies. Aspects of these are commented upon. Copyright 2005, Oxford University Press.

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  • Philip Cooke, 2005. "Rational drug design, the knowledge value chain and bioscience megacentres," Cambridge Journal of Economics, Cambridge Political Economy Society, vol. 29(3), pages 325-341, May.
    • Handle: RePEc:oup:cambje:v:29:y:2005:i:3:p:325-341
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    File URL: http://hdl.handle.net/10.1093/cje/bei045
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    Cited by:

    1. Philip Cooke & Dan Kaufmann & Chen Levin & Rob Wilson, 2006. "‘The Biosciences Knowledge Value Chain and Comparative Incubation Models’," The Journal of Technology Transfer, Springer, vol. 31(1), pages 115-129, January.
    2. Roman Martin, 2012. "Measuring Knowledge Bases in Swedish Regions," European Planning Studies, Taylor & Francis Journals, vol. 20(9), pages 1569-1582, September.
    3. Philip Cooke, 2009. "The Economic Geography Of Knowledge Flow Hierarchies Among Internationally Networked Medical Bioclusters: A Scientometric Analysis," Tijdschrift voor Economische en Sociale Geografie, Royal Dutch Geographical Society KNAG, vol. 100(3), pages 332-347, July.
    4. Sharmistha Bagchi-Sen & Helen Lawton Smith, 2014. "Firm Heterogeneity in Biotech: Absorptive Capacity, Strategies and Local-Regional Connections," European Planning Studies, Taylor & Francis Journals, vol. 22(9), pages 1783-1801, September.
    5. Marina Geenhuizen, 2007. "Modelling dynamics of knowledge networks and local connectedness: a case study of urban high-tech companies in The Netherlands," The Annals of Regional Science, Springer;Western Regional Science Association, vol. 41(4), pages 813-833, December.
    6. Lynne G. Zucker & Michael R. Darby, 2009. "Star Scientists, Innovation and Regional and National Immigration," Chapters, in: David B. Audretsch & Robert E. Litan & Robert Strom (ed.), Entrepreneurship and Openness, chapter 6, Edward Elgar Publishing.
    7. Acosta, Manuel & Coronado, Daniel & Martínez, M. Ángeles, 2012. "Spatial differences in the quality of university patenting: Do regions matter?," Research Policy, Elsevier, vol. 41(4), pages 692-703.
    8. Gilding, Michael & Brennecke, Julia & Bunton, Vikki & Lusher, Dean & Molloy, Peter L. & Codoreanu, Alex, 2020. "Network failure: Biotechnology firms, clusters and collaborations far from the world superclusters," Research Policy, Elsevier, vol. 49(2).
    9. Moodysson , Jerker & Trippl, Michaela & Zukauskaite, Elena, 2015. "Policy Learning and Smart Specialization Balancing Policy Change and Policy Stability for New Regional Industrial Path Development," Papers in Innovation Studies 2015/39, Lund University, CIRCLE - Centre for Innovation Research.
    10. Jayan Jose Thomas, 2008. "Innovation In India And China: Challenges And Prospects In Pharmaceuticals And Biotechnology," Working Papers 2008-035, Madras School of Economics,Chennai,India.
    11. Adelheid Holl & Ruth Rama, 2014. "Foreign Subsidiaries and Technology Sourcing in Spain," Industry and Innovation, Taylor & Francis Journals, vol. 21(1), pages 43-64, January.
    12. Kevin P. Heanue, 2008. "Measuring Industrial Agglomeration in a Rural Industry: The Case of Irish Furniture Manufacturing," Working Papers 0830, Rural Economy and Development Programme,Teagasc.
    13. Denicolai, Stefano & Previtali, Pietro, 2020. "Precision Medicine: Implications for value chains and business models in life sciences," Technological Forecasting and Social Change, Elsevier, vol. 151(C).
    14. Jerker Moodysson & Lars Coenen & Bjørn Asheim, 2008. "Explaining Spatial Patterns of Innovation: Analytical and Synthetic Modes of Knowledge Creation in the Medicon Valley Life-Science Cluster," Environment and Planning A, , vol. 40(5), pages 1040-1056, May.
    15. Bjørn Asheim & Lars Coenen & Jan Vang, 2007. "Face-to-Face, Buzz, and Knowledge Bases: Sociospatial Implications for Learning, Innovation, and Innovation Policy," Environment and Planning C, , vol. 25(5), pages 655-670, October.
    16. Antonelli, Cristiano, 2005. "The Governance Of Localized Knowledge: An Information Economics Approach For The Economics Of Knowledge," Department of Economics and Statistics Cognetti de Martiis LEI & BRICK - Laboratory of Economics of Innovation "Franco Momigliano", Bureau of Research in Innovation, Complexity and Knowledge, Collegio 200502, University of Turin.
    17. Wield, David & Tait, Joyce & Chataway, Joanna & Mittra, James & Mastroeni, Michele, 2017. "Conceptualising and practising multiple knowledge interactions in the life sciences," Technological Forecasting and Social Change, Elsevier, vol. 116(C), pages 308-315.
    18. Pereira, Vijay & Patnaik, Swetketu & Temouri, Yama & Tarba, Shlomo & Malik, Ashish & Bustinza, Oscar, 2021. "A longitudinal micro-foundational investigation into ambidextrous practices in an international alliance context–A case of a biopharma EMNE," International Business Review, Elsevier, vol. 30(1).
    19. Philip Cooke, 2010. "Global Bioregions: Knowledge Domains, Capabilities and Innovation System Networks," Chapters, in: Riccardo Viale & Henry Etzkowitz (ed.), The Capitalization of Knowledge, chapter 5, Edward Elgar Publishing.
    20. Jiang, Zihao & Liu, Zhiying, 2022. "Policies and exploitative and exploratory innovations of the wind power industry in China: The role of technological path dependence," Technological Forecasting and Social Change, Elsevier, vol. 177(C).

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