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Institutional power play in innovation systems: The case of Herceptin®

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  • Kukk, Piret
  • Moors, Ellen H.M.
  • Hekkert, Marko P.

Abstract

New technologies must be accompanied by institutional change. Innovative actors therefore need to do institutional work or take a role as an institutional entrepreneur in order to shape the institutions in the best interests of their technology. However, the literature on system building and on institutional entrepreneurship have little overlap. The goal of this paper is to bridge these two bodies of literature to gain additional insights into how institutional change evolves in a technological innovation system. We show how the pharmaceutical firm Roche acted as a powerful institutional entrepreneur by influencing the health-care system in England to create a market for the personalized cancer drug Herceptin®. We demonstrate that institutional change can be preceded by a range of innovation system-building activities that are not directly intended to bring about institutional change but are required in order for institutional change to take place. Through this case study, we show how the system-building and institutional change literature can complement each other.

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  • Kukk, Piret & Moors, Ellen H.M. & Hekkert, Marko P., 2016. "Institutional power play in innovation systems: The case of Herceptin®," Research Policy, Elsevier, vol. 45(8), pages 1558-1569.
    • Handle: RePEc:eee:respol:v:45:y:2016:i:8:p:1558-1569
    DOI: 10.1016/j.respol.2016.01.016
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    3. Cayetano Medina Molina & Domingo Ribeiro Soriano & Cristina Blanco González-Tejero, 2023. "Multi-level corporate entrepreneurship in SMEs: an intra-metropolitan analysis," Review of Managerial Science, Springer, vol. 17(7), pages 2185-2213, October.
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    5. Hameeda A. AlMalki & Christopher M. Durugbo, 2023. "Systematic review of institutional innovation literature: towards a multi-level management model," Management Review Quarterly, Springer, vol. 73(2), pages 731-785, June.
    6. Gruenhagen, Jan Henrik & Cox, Stephen & Parker, Rachel, 2022. "An actor-oriented perspective on innovation systems: Functional analysis of drivers and barriers to innovation and technology adoption in the mining sector," Technology in Society, Elsevier, vol. 68(C).
    7. Ávila-Robinson, Alfonso & Islam, Nazrul & Sengoku, Shintaro, 2019. "Co-evolutionary and systemic study on the evolution of emerging stem cell-based therapies," Technological Forecasting and Social Change, Elsevier, vol. 138(C), pages 324-339.
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    9. Musiolik, Jörg & Markard, Jochen & Hekkert, Marko & Furrer, Bettina, 2020. "Creating innovation systems: How resource constellations affect the strategies of system builders," Technological Forecasting and Social Change, Elsevier, vol. 153(C).
    10. Albats, Ekaterina & Alexander, Allen T. & Cunningham, James A., 2022. "Traditional, virtual, and digital intermediaries in university-industry collaboration: exploring institutional logics and bounded rationality," Technological Forecasting and Social Change, Elsevier, vol. 177(C).
    11. Cristina Caterina Amitrano & Marco Tregua & Tiziana Russo Spena & Francesco Bifulco, 2018. "On Technology in Innovation Systems and Innovation-Ecosystem Perspectives: A Cross-Linking Analysis," Sustainability, MDPI, vol. 10(10), pages 1-15, October.
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