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Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
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- Yuanyuan Chen & Reka Toth & Sara Chocarro & Dieter Weichenhan & Joschka Hey & Pavlo Lutsik & Stefan Sawall & Georgios T. Stathopoulos & Christoph Plass & Rocio Sotillo, 2022. "Club cells employ regeneration mechanisms during lung tumorigenesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
- Matthew J. Seasock & Md Shafiquzzaman & Maria E. Ruiz-Echartea & Rupa S. Kanchi & Brandon T. Tran & Lukas M. Simon & Matthew D. Meyer & Phillip A. Erice & Shivani L. Lotlikar & Stephanie C. Wenlock & , 2025. "Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
- Marin Truchi & Marine Gautier-Isola & Grégoire Savary & Célia Scribe & Arun Lingampally & Hugo Cadis & Alberto Baeri & Virginie Magnone & Cédric Girard-Riboulleau & Marie-Jeanne Arguel & Clémentine Sc, 2025. "Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice," Nature Communications, Nature, vol. 16(1), pages 1-21, December.
- Yasunori Enomoto & Hiroaki Katsura & Takashi Fujimura & Akira Ogata & Saori Baba & Akira Yamaoka & Miho Kihara & Takaya Abe & Osamu Nishimura & Mitsutaka Kadota & Daisuke Hazama & Yugo Tanaka & Yoshim, 2023. "Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Minzhe Guo & Michael P. Morley & Cheng Jiang & Yixin Wu & Guangyuan Li & Yina Du & Shuyang Zhao & Andrew Wagner & Adnan Cihan Cakar & Michal Kouril & Kang Jin & Nathan Gaddis & Joseph A. Kitzmiller & , 2023. "Guided construction of single cell reference for human and mouse lung," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
- Rachel Warren & Kylie Klinkhammer & Handeng Lyu & Joseph Knopp & Tingting Yuan & Changfu Yao & Barry Stripp & Stijn P. De Langhe, 2024. "Cell competition drives bronchiolization and pulmonary fibrosis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
- Darcy Elizabeth Wagner & Hani N. Alsafadi & Nilay Mitash & Aurelien Justet & Qianjiang Hu & Ricardo Pineda & Claudia Staab-Weijnitz & Martina Korfei & Nika Gvazava & Kristin Wannemo & Ugochi Onwuka & , 2025. "Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
- Leila R. Martins & Lina Sieverling & Michelle Michelhans & Chiara Schiller & Cihan Erkut & Thomas G. P. Grünewald & Sergio Triana & Stefan Fröhling & Lars Velten & Hanno Glimm & Claudia Scholl, 2024. "Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
- Adrian Fischer & Wei Han & Shaoping Hu & Martin Mück-Häusl & Juliane Wannemacher & Safwen Kadri & Yue Lin & Ruoxuan Dai & Simon Christ & Yiqun Su & Bikram Dasgupta & Aydan Sardogan & Christoph Deisenh, 2025. "Targeting pleuro-alveolar junctions reverses lung fibrosis in mice," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
- Bongjun Kim & Yuanjian Huang & Kyung-Pil Ko & Shengzhe Zhang & Gengyi Zou & Jie Zhang & Moon Jong Kim & Danielle Little & Lisandra Vila Ellis & Margherita Paschini & Sohee Jun & Kwon-Sik Park & Jichao, 2024. "PCLAF-DREAM drives alveolar cell plasticity for lung regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Laura Heydemann & Małgorzata Ciurkiewicz & Theresa Störk & Isabel Zdora & Kirsten Hülskötter & Katharina Manuela Gregor & Lukas Mathias Michaely & Wencke Reineking & Tom Schreiner & Georg Beythien & A, 2025. "Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis," Nature Communications, Nature, vol. 16(1), pages 1-24, December.
- Lin Yang & Qiongliang Liu & Pramod Kumar & Arunima Sengupta & Ali Farnoud & Ruolin Shen & Darya Trofimova & Sebastian Ziegler & Neda Davoudi & Ali Doryab & Ali Önder Yildirim & Markus E. Diefenbacher , 2024. "LungVis 1.0: an automatic AI-powered 3D imaging ecosystem unveils spatial profiling of nanoparticle delivery and acinar migration of lung macrophages," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
- Xin Pan & Lan Wang & Juntang Yang & Yingge Li & Min Xu & Chenxi Liang & Lulu Liu & Zhongzheng Li & Cong Xia & Jiaojiao Pang & Mengyuan Wang & Meng Li & Saiya Guo & Peishuo Yan & Chen Ding & Ivan O. Ro, 2024. "TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
- Mayra Cruz Tleugabulova & Sandra P. Melo & Aaron Wong & Alexander Arlantico & Meizi Liu & Joshua D. Webster & Julia Lau & Antonie Lechner & Basak Corak & Jonathan J. Hodgins & Venkata S. Garlapati & M, 2024. "Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
- Sandra Curras-Alonso & Juliette Soulier & Thomas Defard & Christian Weber & Sophie Heinrich & Hugo Laporte & Sophie Leboucher & Sonia Lameiras & Marie Dutreix & Vincent Favaudon & Florian Massip & Tho, 2023. "An interactive murine single-cell atlas of the lung responses to radiation injury," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Christina Beck & Deepak Ramanujam & Paula Vaccarello & Florenc Widenmeyer & Martin Feuerherd & Cho-Chin Cheng & Anton Bomhard & Tatiana Abikeeva & Julia Schädler & Jan-Peter Sperhake & Matthias Graw &, 2023. "Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
- Ahmed A. Raslan & Tho X. Pham & Jisu Lee & Konstantinos Kontodimas & Andrew Tilston-Lunel & Jillian Schmottlach & Jeongmin Hong & Taha Dinc & Andreea M. Bujor & Nunzia Caporarello & Aude Thiriot & Ulr, 2024. "Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
- Laura Heydemann & Małgorzata Ciurkiewicz & Georg Beythien & Kathrin Becker & Klaus Schughart & Stephanie Stanelle-Bertram & Berfin Schaumburg & Nancy Mounogou-Kouassi & Sebastian Beck & Martin Zickler, 2023. "Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
- Xi Wang & Shlomi Brielle & Jennifer Kenty-Ryu & Nataly Korover & Danny Bavli & Ramona Pop & Douglas A. Melton, 2025. "Improving cellular fitness of human stem cell-derived islets under hypoxia," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
- Dalia Hassan & Jichao Chen, 2024. "CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
- Xianzhu Zhang & Wei Jiang & Xinyu Wu & Chang Xie & Yi Zhang & Liying Li & Yuqing Gu & Zihao Hu & Xinrang Zhai & Renjie Liang & Tao Zhang & Wei Sun & Jinchun Ye & Wei Wei & Xiaozhao Wang & Yi Hong & Sh, 2025. "Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment," Nature Communications, Nature, vol. 16(1), pages 1-23, December.
- Jing Yan & Song-Yu Wang & Qi Su & Min-Wen Zou & Zi-Yue Zhou & Jian Shou & Yunlong Huo, 2025. "Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
- Lucy Xia & Christy Lee & Jingyi Jessica Li, 2024. "Statistical method scDEED for detecting dubious 2D single-cell embeddings and optimizing t-SNE and UMAP hyperparameters," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
- Safwen Kadri & Adrian Fischer & Martin Mück-Häusl & Wei Han & Amal Kadri & Yue Lin & Lin Yang & Shaoping Hu & Haifeng Ye & Pushkar Ramesh & Meshal Ansari & Herbert B. Schiller & Hans-Günther Machens &, 2025. "A mesothelial differentiation gateway drives fibrosis," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
- Andrea Toth & Paranthaman Kannan & John Snowball & Matthew Kofron & Joseph A. Wayman & James P. Bridges & Emily R. Miraldi & Daniel Swarr & William J. Zacharias, 2023. "Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
- Jiawen Hou & Wei Zhao & Qing Nie, 2025. "Dissecting crosstalk induced by cell-cell communication using single-cell transcriptomic data," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
- Christopher W. Murray & Jennifer J. Brady & Mingqi Han & Hongchen Cai & Min K. Tsai & Sarah E. Pierce & Ran Cheng & Janos Demeter & David M. Feldser & Peter K. Jackson & David B. Shackelford & Monte M, 2022. "LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
- Benjamin Ng & Kevin Y. Huang & Chee Jian Pua & Sivakumar Viswanathan & Wei-Wen Lim & Fathima F. Kuthubudeen & Yu-Ning Liu & An An Hii & Benjamin L. George & Anissa A. Widjaja & Enrico Petretto & Stuar, 2024. "Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.