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Modelling in Ecomomic Evaluation: An Unavoidable Fact of Life


  • Martin J. Buxton

    (Health Economics Research Group, Brunel University, UK)

  • Michael F. Drummond

    (Centre for Health Economics, University of York, UK)

  • Ben A. Van Hout

    (Institute for Medical Technology Assessment, Erasmus University Rotterdam, The Netherlands)

  • Richard L. Prince

    (Department of Medicine, Queen Elizabeth II Medical Centre, University of Western Australia, Australia)

  • Trevor A. Sheldon

    (Centre for Reviews and Dissemination, University of York, UK)

  • Thomas Szucs

    (Medical Economics Research Group and University of Munich, Germany)

  • Muriel Vray

    (Institut National de la Santé et de la Recherche Médicale, Villejuif, France)


The role of modelling in economic evaluation is explored by discussing, with examples, the uses of models. The expanded use of pragmatic clinical trials as an alternative to models is discussed. Some suggestions for good modelling practice are made. © 1997 by John Wiley & Sons, Ltd.

Suggested Citation

  • Martin J. Buxton & Michael F. Drummond & Ben A. Van Hout & Richard L. Prince & Trevor A. Sheldon & Thomas Szucs & Muriel Vray, 1997. "Modelling in Ecomomic Evaluation: An Unavoidable Fact of Life," Health Economics, John Wiley & Sons, Ltd., vol. 6(3), pages 217-227.
  • Handle: RePEc:wly:hlthec:v:6:y:1997:i:3:p:217-227
    DOI: 10.1002/(SICI)1099-1050(199705)6:3<217::AID-HEC267>3.0.CO;2-W

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    Cited by:

    1. Warburton, Rebecca Nunn, 2005. "Patient safety -- how much is enough?," Health Policy, Elsevier, vol. 71(2), pages 223-232, February.
    2. Syed Mohiuddin, 2014. "A Systematic and Critical Review of Model-Based Economic Evaluations of Pharmacotherapeutics in Patients with Bipolar Disorder," Applied Health Economics and Health Policy, Springer, vol. 12(4), pages 359-372, August.
    3. Hossein Haji Ali Afzali & Jonathan Karnon & Jodi Gray, 2012. "A proposed model for economic evaluations of major depressive disorder," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 13(4), pages 501-510, August.
    4. Wagstaff, Adam & Culyer, Anthony J., 2012. "Four decades of health economics through a bibliometric lens," Journal of Health Economics, Elsevier, vol. 31(2), pages 406-439.
    5. Ziebarth, Deborah, 2016. "Altruistic and economic measurements used for prevention health services: Faith community nursing program," Evaluation and Program Planning, Elsevier, vol. 57(C), pages 72-79.
    6. Sun-Young Kim & Sue Goldie, 2008. "Cost-Effectiveness Analyses of Vaccination Programmes," PharmacoEconomics, Springer, vol. 26(3), pages 191-215, March.
    7. Grieve, Richard & Hutton, John & Green, Colin, 2003. "Selecting methods for the prediction of future events in cost-effectiveness models: a decision-framework and example from the cardiovascular field," Health Policy, Elsevier, vol. 64(3), pages 311-324, June.
    8. Cookson, Richard & Hutton, John, 2003. "Regulating the economic evaluation of pharmaceuticals and medical devices: a European perspective," Health Policy, Elsevier, vol. 63(2), pages 167-178, February.
    9. Freemantle, Nick, 1999. "Does the UK National Health Service need a fourth hurdle for pharmaceutical reimbursement to encourage the more efficient prescribing of pharmaceuticals?," Health Policy, Elsevier, vol. 46(3), pages 255-265, March.
    10. An Tran-Duy & Annelies Boonen & Wietske Kievit & Piet Riel & Mart Laar & Johan Severens, 2014. "Modelling Outcomes of Complex Treatment Strategies Following a Clinical Guideline for Treatment Decisions in Patients with Rheumatoid Arthritis," PharmacoEconomics, Springer, vol. 32(10), pages 1015-1028, October.
    11. van Os, Nicole & Niessen, Louis W. & Bilo, Henk J. G. & Casparie, Anton F. & van Hout, Ben A., 2000. "Diabetes nephropathy in the Netherlands: a cost effectiveness analysis of national clinical guidelines," Health Policy, Elsevier, vol. 51(3), pages 135-147, April.
    12. Cleemput, Irina & Kesteloot, Katrien & DeGeest, Sabina, 2002. "A review of the literature on the economics of noncompliance. Room for methodological improvement," Health Policy, Elsevier, vol. 59(1), pages 65-94, January.
    13. Cannon, Jeffrey W. & Mueller, Ute A. & Hornbuckle, Janet & Larson, Ann & Simmer, Karen & Newnham, John P. & Doherty, Dorota A., 2013. "Economic implications of poor access to antenatal care in rural and remote Western Australian Aboriginal communities: An individual sampling model of pregnancy," European Journal of Operational Research, Elsevier, vol. 226(2), pages 313-324.
    14. Afschin Gandjour & Amiram Gafni, 2013. "Internal validation of models with several interventions," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 14(6), pages 901-909, December.

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