IDEAS home Printed from https://ideas.repec.org/a/taf/jnlasa/v111y2016i514p500-509.html
   My bibliography  Save this article

Calibrating Functional Parameters in the Ion Channel Models of Cardiac Cells

Author

Listed:
  • Matthew Plumlee
  • V. Roshan Joseph
  • Hui Yang

Abstract

Computational modeling is a popular tool to understand a diverse set of complex systems. The output from a computational model depends on a set of parameters that are unknown to the designer, but a modeler can estimate them by collecting physical data. In the described study of the ion channels of ventricular myocytes, the parameter of interest is a function as opposed to a scalar or a set of scalars. This article develops a new modeling strategy to nonparametrically study the functional parameter using Bayesian inference with Gaussian process prior distributions. A new sampling scheme is devised to address this unique problem.

Suggested Citation

  • Matthew Plumlee & V. Roshan Joseph & Hui Yang, 2016. "Calibrating Functional Parameters in the Ion Channel Models of Cardiac Cells," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(514), pages 500-509, April.
    • Handle: RePEc:taf:jnlasa:v:111:y:2016:i:514:p:500-509
    DOI: 10.1080/01621459.2015.1119695
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/01621459.2015.1119695
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/01621459.2015.1119695?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Higdon, Dave & Gattiker, James & Williams, Brian & Rightley, Maria, 2008. "Computer Model Calibration Using High-Dimensional Output," Journal of the American Statistical Association, American Statistical Association, vol. 103, pages 570-583, June.
    2. Marc C. Kennedy & Anthony O'Hagan, 2001. "Bayesian calibration of computer models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 63(3), pages 425-464.
    3. Pablo Achard & Erik De Schutter, 2006. "Complex Parameter Landscape for a Complex Neuron Model," PLOS Computational Biology, Public Library of Science, vol. 2(7), pages 1-11, July.
    4. J. O. Ramsay & G. Hooker & D. Campbell & J. Cao, 2007. "Parameter estimation for differential equations: a generalized smoothing approach," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 69(5), pages 741-796, November.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Matthew Plumlee, 2017. "Bayesian Calibration of Inexact Computer Models," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(519), pages 1274-1285, July.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Drignei, Dorin, 2011. "A general statistical model for computer experiments with time series output," Reliability Engineering and System Safety, Elsevier, vol. 96(4), pages 460-467.
    2. Hwang, Youngdeok & Kim, Hang J. & Chang, Won & Yeo, Kyongmin & Kim, Yongku, 2019. "Bayesian pollution source identification via an inverse physics model," Computational Statistics & Data Analysis, Elsevier, vol. 134(C), pages 76-92.
    3. Ioannis Andrianakis & Ian R Vernon & Nicky McCreesh & Trevelyan J McKinley & Jeremy E Oakley & Rebecca N Nsubuga & Michael Goldstein & Richard G White, 2015. "Bayesian History Matching of Complex Infectious Disease Models Using Emulation: A Tutorial and a Case Study on HIV in Uganda," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-18, January.
    4. Samantha M. Roth & Ben Seiyon Lee & Sanjib Sharma & Iman Hosseini‐Shakib & Klaus Keller & Murali Haran, 2023. "Flood hazard model calibration using multiresolution model output," Environmetrics, John Wiley & Sons, Ltd., vol. 34(2), March.
    5. Perrin, G., 2020. "Adaptive calibration of a computer code with time-series output," Reliability Engineering and System Safety, Elsevier, vol. 196(C).
    6. White, Staci A. & Herbei, Radu, 2015. "A Monte Carlo approach to quantifying model error in Bayesian parameter estimation," Computational Statistics & Data Analysis, Elsevier, vol. 83(C), pages 168-181.
    7. Mevin Hooten & Christopher Wikle & Michael Schwob, 2020. "Statistical Implementations of Agent‐Based Demographic Models," International Statistical Review, International Statistical Institute, vol. 88(2), pages 441-461, August.
    8. Leatherman, Erin R. & Dean, Angela M. & Santner, Thomas J., 2017. "Designing combined physical and computer experiments to maximize prediction accuracy," Computational Statistics & Data Analysis, Elsevier, vol. 113(C), pages 346-362.
    9. Wu, Xu & Kozlowski, Tomasz & Meidani, Hadi, 2018. "Kriging-based inverse uncertainty quantification of nuclear fuel performance code BISON fission gas release model using time series measurement data," Reliability Engineering and System Safety, Elsevier, vol. 169(C), pages 422-436.
    10. Nott, David J. & Marshall, Lucy & Fielding, Mark & Liong, Shie-Yui, 2014. "Mixtures of experts for understanding model discrepancy in dynamic computer models," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 491-505.
    11. Paulo, Rui & García-Donato, Gonzalo & Palomo, Jesús, 2012. "Calibration of computer models with multivariate output," Computational Statistics & Data Analysis, Elsevier, vol. 56(12), pages 3959-3974.
    12. Jackson Samuel E. & Vernon Ian & Liu Junli & Lindsey Keith, 2020. "Understanding hormonal crosstalk in Arabidopsis root development via emulation and history matching," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 19(2), pages 1-33, April.
    13. Guillaume Perrin & Christian Soize, 2020. "Adaptive method for indirect identification of the statistical properties of random fields in a Bayesian framework," Computational Statistics, Springer, vol. 35(1), pages 111-133, March.
    14. Stripling, H.F. & Adams, M.L. & McClarren, R.G. & Mallick, B.K., 2011. "The Method of Manufactured Universes for validating uncertainty quantification methods," Reliability Engineering and System Safety, Elsevier, vol. 96(9), pages 1242-1256.
    15. Matthew Plumlee, 2014. "Fast Prediction of Deterministic Functions Using Sparse Grid Experimental Designs," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(508), pages 1581-1591, December.
    16. SungKu Kang & Ran Jin & Xinwei Deng & Ron S. Kenett, 2023. "Challenges of modeling and analysis in cybermanufacturing: a review from a machine learning and computation perspective," Journal of Intelligent Manufacturing, Springer, vol. 34(2), pages 415-428, February.
    17. Manfren, Massimiliano & Aste, Niccolò & Moshksar, Reza, 2013. "Calibration and uncertainty analysis for computer models – A meta-model based approach for integrated building energy simulation," Applied Energy, Elsevier, vol. 103(C), pages 627-641.
    18. Daniel W. Gladish & Daniel E. Pagendam & Luk J. M. Peeters & Petra M. Kuhnert & Jai Vaze, 2018. "Emulation Engines: Choice and Quantification of Uncertainty for Complex Hydrological Models," Journal of Agricultural, Biological and Environmental Statistics, Springer;The International Biometric Society;American Statistical Association, vol. 23(1), pages 39-62, March.
    19. Chen, Yewen & Chang, Xiaohui & Luo, Fangzhi & Huang, Hui, 2023. "Additive dynamic models for correcting numerical model outputs," Computational Statistics & Data Analysis, Elsevier, vol. 187(C).
    20. Kim, Wongon & Yoon, Heonjun & Lee, Guesuk & Kim, Taejin & Youn, Byeng D., 2020. "A new calibration metric that considers statistical correlation: Marginal Probability and Correlation Residuals," Reliability Engineering and System Safety, Elsevier, vol. 195(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:jnlasa:v:111:y:2016:i:514:p:500-509. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/UASA20 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.