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Censored mixed-effects models for irregularly observed repeated measures with applications to HIV viral loads

Author

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  • Larissa A. Matos

    (Universidade Estadual de Campinas)

  • Luis M. Castro

    (Universidad de Concepción)

  • Víctor H. Lachos

    (Universidade Estadual de Campinas)

Abstract

In some acquired immunodeficiency syndrome (AIDS) clinical trials, the human immunodeficiency virus-1 ribonucleic acid measurements are collected irregularly over time and are often subject to some upper and lower detection limits, depending on the quantification assays. Linear and nonlinear mixed-effects models, with modifications to accommodate censored observations, are routinely used to analyze this type of data (Vaida and Liu, J Comput Graph Stat 18:797–817, 2009; Matos et al., Comput Stat Data Anal 57(1):450–464, 2013a). This paper presents a framework for fitting LMEC/NLMEC with response variables recorded at irregular intervals. To address the serial correlation among the within-subject errors, a damped exponential correlation structure is considered in the random error and an EM-type algorithm is developed for computing the maximum likelihood estimates, obtaining as a byproduct the standard errors of the fixed effects and the likelihood value. The proposed methods are illustrated with simulations and the analysis of two real AIDS case studies.

Suggested Citation

  • Larissa A. Matos & Luis M. Castro & Víctor H. Lachos, 2016. "Censored mixed-effects models for irregularly observed repeated measures with applications to HIV viral loads," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 25(4), pages 627-653, December.
    • Handle: RePEc:spr:testjl:v:25:y:2016:i:4:d:10.1007_s11749-016-0486-2
    DOI: 10.1007/s11749-016-0486-2
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    References listed on IDEAS

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    9. Matos, Larissa A. & Bandyopadhyay, Dipankar & Castro, Luis M. & Lachos, Victor H., 2015. "Influence assessment in censored mixed-effects models using the multivariate Student’s-t distribution," Journal of Multivariate Analysis, Elsevier, vol. 141(C), pages 104-117.
    10. Samson, Adeline & Lavielle, Marc & Mentre, France, 2006. "Extension of the SAEM algorithm to left-censored data in nonlinear mixed-effects model: Application to HIV dynamics model," Computational Statistics & Data Analysis, Elsevier, vol. 51(3), pages 1562-1574, December.
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    Cited by:

    1. Larissa A. Matos & Víctor H. Lachos & Tsung-I Lin & Luis M. Castro, 2019. "Heavy-tailed longitudinal regression models for censored data: a robust parametric approach," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 28(3), pages 844-878, September.
    2. Carlos A. Coelho & Anuradha Roy, 2017. "Testing the hypothesis of a block compound symmetric covariance matrix for elliptically contoured distributions," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 26(2), pages 308-330, June.
    3. Francisco H. C. Alencar & Larissa A Matos & Víctor H. Lachos, 2022. "Finite Mixture of Censored Linear Mixed Models for Irregularly Observed Longitudinal Data," Journal of Classification, Springer;The Classification Society, vol. 39(3), pages 463-486, November.

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