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A randomized two stage allocation for continuous response clinical trials

Author

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  • Rahul Bhattacharya
  • Madhumita Shome

Abstract

A randomized two treatment allocation design, conducted in two stages, is proposed for a class of continuous response trials. Patients are assigned to each treatment in equal numbers in the first stage and p value of a test of equality of treatment effects based on these data is used to determine the assignment probability of second stage patients. Relevant properties of the proposed allocation design are investigated and compared with suitable competitors. Copyright Springer-Verlag Berlin Heidelberg 2015

Suggested Citation

  • Rahul Bhattacharya & Madhumita Shome, 2015. "A randomized two stage allocation for continuous response clinical trials," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 24(3), pages 373-386, September.
    • Handle: RePEc:spr:stmapp:v:24:y:2015:i:3:p:373-386
    DOI: 10.1007/s10260-014-0267-6
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    References listed on IDEAS

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    1. Lanju Zhang & William F. Rosenberger, 2006. "Response-Adaptive Randomization for Clinical Trials with Continuous Outcomes," Biometrics, The International Biometric Society, vol. 62(2), pages 562-569, June.
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