IDEAS home Printed from https://ideas.repec.org/a/spr/stabio/v12y2020i1d10.1007_s12561-019-09242-6.html
   My bibliography  Save this article

Two-Way Horizontal and Vertical Omics Integration for Disease Subtype Discovery

Author

Listed:
  • Zhiguang Huo

    (University of Florida)

  • Li Zhu

    (University of Pittsburgh)

  • Tianzhou Ma

    (University of Maryland)

  • Hongcheng Liu

    (University of Florida)

  • Song Han

    (University of Florida)

  • Daiqing Liao

    (University of Florida)

  • Jinying Zhao

    (University of Florida)

  • George Tseng

    (University of Pittsburgh)

Abstract

Disease subtype discovery is an essential step in delivering personalized medicine. Disease subtyping via omics data has become a common approach for this purpose. With the advancement of technology and the lower price for generating omics data, multi-level and multi-cohort omics data are prevalent in the public domain, providing unprecedented opportunities to decrypt disease mechanisms. How to fully utilize multi-level/multi-cohort omics data and incorporate established biological knowledge toward disease subtyping remains a challenging problem. In this paper, we propose a meta-analytic integrative sparse Kmeans (MISKmeans) algorithm for integrating multi-cohort/multi-level omics data and prior biological knowledge. Compared with previous methods, MISKmeans shows better clustering accuracy and feature selection relevancy. An efficient R package, “MIS-Kmeans”, calling C++ is freely available on GitHub (https://github.com/Caleb-Huo/MIS-Kmeans).

Suggested Citation

  • Zhiguang Huo & Li Zhu & Tianzhou Ma & Hongcheng Liu & Song Han & Daiqing Liao & Jinying Zhao & George Tseng, 2020. "Two-Way Horizontal and Vertical Omics Integration for Disease Subtype Discovery," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 12(1), pages 1-22, April.
    • Handle: RePEc:spr:stabio:v:12:y:2020:i:1:d:10.1007_s12561-019-09242-6
    DOI: 10.1007/s12561-019-09242-6
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s12561-019-09242-6
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s12561-019-09242-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Ronglai Shen & Qianxing Mo & Nikolaus Schultz & Venkatraman E Seshan & Adam B Olshen & Jason Huse & Marc Ladanyi & Chris Sander, 2012. "Integrative Subtype Discovery in Glioblastoma Using iCluster," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-9, April.
    2. Robert Tibshirani & Guenther Walther & Trevor Hastie, 2001. "Estimating the number of clusters in a data set via the gap statistic," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 63(2), pages 411-423.
    3. Zhiguang Huo & Ying Ding & Silvia Liu & Steffi Oesterreich & George Tseng, 2016. "Meta-Analytic Framework for Sparse K -Means to Identify Disease Subtypes in Multiple Transcriptomic Studies," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(513), pages 27-42, March.
    4. Glenn Milligan & Martha Cooper, 1985. "An examination of procedures for determining the number of clusters in a data set," Psychometrika, Springer;The Psychometric Society, vol. 50(2), pages 159-179, June.
    5. Charles M. Perou & Therese Sørlie & Michael B. Eisen & Matt van de Rijn & Stefanie S. Jeffrey & Christian A. Rees & Jonathan R. Pollack & Douglas T. Ross & Hilde Johnsen & Lars A. Akslen & Øystein Flu, 2000. "Molecular portraits of human breast tumours," Nature, Nature, vol. 406(6797), pages 747-752, August.
    6. Lawrence Hubert & Phipps Arabie, 1985. "Comparing partitions," Journal of Classification, Springer;The Classification Society, vol. 2(1), pages 193-218, December.
    7. Adaikalavan Ramasamy & Adrian Mondry & Chris C Holmes & Douglas G Altman, 2008. "Key Issues in Conducting a Meta-Analysis of Gene Expression Microarray Datasets," PLOS Medicine, Public Library of Science, vol. 5(9), pages 1-13, September.
    8. Patrick Danaher & Pei Wang & Daniela M. Witten, 2014. "The joint graphical lasso for inverse covariance estimation across multiple classes," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 76(2), pages 373-397, March.
    9. Witten, Daniela M. & Tibshirani, Robert, 2010. "A Framework for Feature Selection in Clustering," Journal of the American Statistical Association, American Statistical Association, vol. 105(490), pages 713-726.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lingsong Meng & Dorina Avram & George Tseng & Zhiguang Huo, 2022. "Outcome‐guided sparse K‐means for disease subtype discovery via integrating phenotypic data with high‐dimensional transcriptomic data," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 71(2), pages 352-375, March.
    2. J. Fernando Vera & Rodrigo Macías, 2021. "On the Behaviour of K-Means Clustering of a Dissimilarity Matrix by Means of Full Multidimensional Scaling," Psychometrika, Springer;The Psychometric Society, vol. 86(2), pages 489-513, June.
    3. Zhiguang Huo & Ying Ding & Silvia Liu & Steffi Oesterreich & George Tseng, 2016. "Meta-Analytic Framework for Sparse K -Means to Identify Disease Subtypes in Multiple Transcriptomic Studies," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 111(513), pages 27-42, March.
    4. Li, Pai-Ling & Chiou, Jeng-Min, 2011. "Identifying cluster number for subspace projected functional data clustering," Computational Statistics & Data Analysis, Elsevier, vol. 55(6), pages 2090-2103, June.
    5. Yaeji Lim & Hee-Seok Oh & Ying Kuen Cheung, 2019. "Multiscale Clustering for Functional Data," Journal of Classification, Springer;The Classification Society, vol. 36(2), pages 368-391, July.
    6. Dong Liu & Changwei Zhao & Yong He & Lei Liu & Ying Guo & Xinsheng Zhang, 2023. "Simultaneous cluster structure learning and estimation of heterogeneous graphs for matrix‐variate fMRI data," Biometrics, The International Biometric Society, vol. 79(3), pages 2246-2259, September.
    7. Julian Rossbroich & Jeffrey Durieux & Tom F. Wilderjans, 2022. "Model Selection Strategies for Determining the Optimal Number of Overlapping Clusters in Additive Overlapping Partitional Clustering," Journal of Classification, Springer;The Classification Society, vol. 39(2), pages 264-301, July.
    8. Weinand, J.M. & McKenna, R. & Fichtner, W., 2019. "Developing a municipality typology for modelling decentralised energy systems," Utilities Policy, Elsevier, vol. 57(C), pages 75-96.
    9. Fang, Yixin & Wang, Junhui, 2012. "Selection of the number of clusters via the bootstrap method," Computational Statistics & Data Analysis, Elsevier, vol. 56(3), pages 468-477.
    10. Dario Bruzzese & Domenico Vistocco, 2015. "DESPOTA: DEndrogram Slicing through a PemutatiOn Test Approach," Journal of Classification, Springer;The Classification Society, vol. 32(2), pages 285-304, July.
    11. Douglas Steinley, 2007. "Validating Clusters with the Lower Bound for Sum-of-Squares Error," Psychometrika, Springer;The Psychometric Society, vol. 72(1), pages 93-106, March.
    12. Clémençon, Stéphan, 2014. "A statistical view of clustering performance through the theory of U-processes," Journal of Multivariate Analysis, Elsevier, vol. 124(C), pages 42-56.
    13. Kaczynska, S. & Marion, R. & Von Sachs, R., 2020. "Comparison of Cluster Validity Indices and Decision Rules for Different Degrees of Cluster Separation," LIDAM Discussion Papers ISBA 2020009, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    14. Ranjan Maitra & Ivan P. Ramler, 2009. "Clustering in the Presence of Scatter," Biometrics, The International Biometric Society, vol. 65(2), pages 341-352, June.
    15. Fordellone, Mario & Vichi, Maurizio, 2020. "Finding groups in structural equation modeling through the partial least squares algorithm," Computational Statistics & Data Analysis, Elsevier, vol. 147(C).
    16. Batool, Fatima & Hennig, Christian, 2021. "Clustering with the Average Silhouette Width," Computational Statistics & Data Analysis, Elsevier, vol. 158(C).
    17. Yujia Li & Xiangrui Zeng & Chien‐Wei Lin & George C. Tseng, 2022. "Simultaneous estimation of cluster number and feature sparsity in high‐dimensional cluster analysis," Biometrics, The International Biometric Society, vol. 78(2), pages 574-585, June.
    18. Ana Helena Tavares & Jakob Raymaekers & Peter J. Rousseeuw & Paula Brito & Vera Afreixo, 2020. "Clustering genomic words in human DNA using peaks and trends of distributions," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 14(1), pages 57-76, March.
    19. Jeffrey Andrews & Paul McNicholas, 2014. "Variable Selection for Clustering and Classification," Journal of Classification, Springer;The Classification Society, vol. 31(2), pages 136-153, July.
    20. Alessandro Casa & Andrea Cappozzo & Michael Fop, 2022. "Group-Wise Shrinkage Estimation in Penalized Model-Based Clustering," Journal of Classification, Springer;The Classification Society, vol. 39(3), pages 648-674, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:stabio:v:12:y:2020:i:1:d:10.1007_s12561-019-09242-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.