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Contextual Considerations and Recommendations for Estimating the Value of Alzheimer’s Disease Therapies

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  • T. Joseph Mattingly

    (Patient-Driven Values in Healthcare Evaluation (PAVE) Center at the University of Maryland School of Pharmacy)

  • R. Brett McQueen

    (University of Colorado Anschutz Medical Campus)

  • Pei-Jung Lin

    (Tufts Medical Center)

Abstract

The pipeline for new treatments for Alzheimer’s disease (AD) in the USA contains over 100 different agents, 80% of which can be categorized as disease-modifying therapies. The regulatory approval of the disease-modifying agent aducanumab has brought more attention to the complexity of the diagnosis, evaluation, and treatment of AD and the difficult decisions payers and policy makers will face over the next few years as innovation continues in this space. The value of AD treatment can vary widely according to the perspective of the analysis, sources of data, and methodological approach for the value assessment. This article focuses on AD-specific data gaps and measurement challenges and provides guidance for evidence generation to facilitate better value assessments for future AD treatments.

Suggested Citation

  • T. Joseph Mattingly & R. Brett McQueen & Pei-Jung Lin, 2021. "Contextual Considerations and Recommendations for Estimating the Value of Alzheimer’s Disease Therapies," PharmacoEconomics, Springer, vol. 39(10), pages 1101-1107, October.
    • Handle: RePEc:spr:pharme:v:39:y:2021:i:10:d:10.1007_s40273-021-01079-6
    DOI: 10.1007/s40273-021-01079-6
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    References listed on IDEAS

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    1. Nagede Costa & Helene Derumeaux & Thomas Rapp & Valérie Garnault & Laura Ferlicoq & Sophie Gillette & Sandrine Andrieu & Bruno Vellas & Michel Lamure & Alain Grand & Laurent Molinier, 2012. "Methodological considerations in cost of illness studies on Alzheimer disease," Health Economics Review, Springer, vol. 2(1), pages 1-12, December.
    2. T. Joseph Mattingly & Julia F. Slejko & Eleanor M. Perfetto & Shyamasundaran Kottilil & C. Daniel Mullins, 2019. "What Matters Most for Treatment Decisions in Hepatitis C: Effectiveness, Costs, and Altruism," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 12(6), pages 631-638, December.
    3. Susan dosReis & Beverly Butler & Juan Caicedo & Annie Kennedy & Yoon Duk Hong & Chengchen Zhang & Julia F. Slejko, 2020. "Stakeholder-Engaged Derivation of Patient-Informed Value Elements," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 13(5), pages 611-621, October.
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