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Nonparametric inference in the accelerated failure time model using restricted means

Author

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  • Mihai C. Giurcanu

    (University of Chicago)

  • Theodore G. Karrison

    (University of Chicago)

Abstract

We propose a nonparametric estimate of the scale-change parameter for characterizing the difference between two survival functions under the accelerated failure time model using an estimating equation based on restricted means. Advantages of our restricted means based approach compared to current nonparametric procedures is the strictly monotone nature of the estimating equation as a function of the scale-change parameter, leading to a unique root, as well as the availability of a direct standard error estimate, avoiding the need for hazard function estimation or re-sampling to conduct inference. We derive the asymptotic properties of the proposed estimator for fixed and for random point of restriction. In a simulation study, we compare the performance of the proposed estimator with parametric and nonparametric competitors in terms of bias, efficiency, and accuracy of coverage probabilities. The restricted means based approach provides unbiased estimates and accurate confidence interval coverage rates with efficiency ranging from 81% to 95% relative to fitting the correct parametric model. An example from a randomized clinical trial in head and neck cancer is provided to illustrate an application of the methodology in practice.

Suggested Citation

  • Mihai C. Giurcanu & Theodore G. Karrison, 2022. "Nonparametric inference in the accelerated failure time model using restricted means," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(1), pages 23-39, January.
    • Handle: RePEc:spr:lifeda:v:28:y:2022:i:1:d:10.1007_s10985-021-09541-5
    DOI: 10.1007/s10985-021-09541-5
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    References listed on IDEAS

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    1. Lihui Zhao & Brian Claggett & Lu Tian & Hajime Uno & Marc A. Pfeffer & Scott D. Solomon & Lorenzo Trippa & L. J. Wei, 2016. "On the restricted mean survival time curve in survival analysis," Biometrics, The International Biometric Society, vol. 72(1), pages 215-221, March.
    2. Lu Tian & Hua Jin & Hajime Uno & Ying Lu & Bo Huang & Keaven M. Anderson & LJ Wei, 2020. "On the empirical choice of the time window for restricted mean survival time," Biometrics, The International Biometric Society, vol. 76(4), pages 1157-1166, December.
    3. Ao Yuan & Mihai Giurcanu & George Luta & Ming T. Tan, 2017. "U-statistics with conditional kernels for incomplete data models," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 69(2), pages 271-302, April.
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