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The relationship between target joints and direct resource use in severe haemophilia

Author

Listed:
  • Jamie O’Hara

    (University of Chester)

  • Shaun Walsh

    (HCD Economics, The Innovation Centre)

  • Charlotte Camp

    (HCD Economics, The Innovation Centre)

  • Giuseppe Mazza

    (University College London)

  • Liz Carroll

    (The Haemophilia Society)

  • Christina Hoxer

    (Novo Nordisk A/S)

  • Lars Wilkinson

    (Novo Nordisk A/S)

Abstract

Objectives Target joints are a common complication of severe haemophilia. While factor replacement therapy constitutes the majority of costs in haemophilia, the relationship between target joints and non drug-related direct costs (NDDCs) has not been studied. Methods Data on haemophilia patients without inhibitors was drawn from the ‘Cost of Haemophilia across Europe – a Socioeconomic Survey’ (CHESS) study, a cost assessment in severe haemophilia A and B across five European countries (France, Germany, Italy, Spain, and the United Kingdom) in which 139 haemophilia specialists provided demographic and clinical information for 1285 adult patients. NDDCs were calculated using publicly available cost data, including 12-month ambulatory and secondary care activity: haematologist and other specialist consultant consultations, medical tests and examinations, bleed-related hospital admissions, and payments to professional care providers. A generalized linear model was developed to investigate the relationship between NDDCs and target joints (areas of chronic synovitis), adjusted for patient covariates. Results Five hundred and thirteen patients (42% of the sample) had no diagnosed target joints; a total of 1376 target joints (range 1–10) were recorded in the remaining 714 patients. Mean adjusted NDDCs for persons with no target joints were EUR 3134 (standard error (SE) EUR 158); for persons with one or more target joints, mean adjusted NDDCs were EUR 3913 (SE EUR 157; average mean effect EUR 779; p

Suggested Citation

  • Jamie O’Hara & Shaun Walsh & Charlotte Camp & Giuseppe Mazza & Liz Carroll & Christina Hoxer & Lars Wilkinson, 2018. "The relationship between target joints and direct resource use in severe haemophilia," Health Economics Review, Springer, vol. 8(1), pages 1-7, December.
    • Handle: RePEc:spr:hecrev:v:8:y:2018:i:1:d:10.1186_s13561-018-0185-7
    DOI: 10.1186/s13561-018-0185-7
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    References listed on IDEAS

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    1. Glick, Henry A. & Doshi, Jalpa A. & Sonnad, Seema S. & Polsky, Daniel, 2014. "Economic Evaluation in Clinical Trials," OUP Catalogue, Oxford University Press, edition 2, number 9780199685028, Decembrie.
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