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The Real-World Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Stenting in High-Risk Patients: Propensity Score-Matched Analysis of a Single-Centre Experience


  • Thathya V. Ariyaratne

    (Monash University)

  • Zanfina Ademi

    (Monash University
    University of Basel)

  • Molla Huq

    (University of Melbourne)

  • Franklin Rosenfeldt

    (Monash University
    Baker Heart and Diabetes Institute)

  • Stephen J. Duffy

    (Monash University
    Alfred Hospital)

  • Bonny Parkinson

    (Macquarie University)

  • Cheng-Hon Yap

    (Monash University
    Geelong Hospital)

  • Julian Smith

    (Monash University)

  • Baki Billah

    (Monash University)

  • Bryan P. Yan

    (Monash University
    Chinese University of Hong Kong)

  • Angela L. Brennan

    (Monash University)

  • Lavinia Tran

    (Monash University)

  • Christopher M. Reid

    (Monash University
    Curtin University)


Background There are limited economic evaluations comparing coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for multi-vessel coronary artery disease (MVCAD) in contemporary, routine clinical practice. Objective The aim was to perform a cost-effectiveness analysis comparing CABG and PCI in patients with MVCAD, from the perspective of the Australian public hospital payer, using observational data sources. Methods Clinical data from the Melbourne Interventional Group (MIG) and the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) registries were analysed for 1022 CABG (treatment) and 978 PCI (comparator) procedures performed between June 2009 and December 2013. Clinical records were linked to same-hospital admissions and national death index (NDI) data. The incremental cost-effectiveness ratios (ICERs) per major adverse cardiac and cerebrovascular event (MACCE) avoided were evaluated. The propensity score bin bootstrap (PSBB) approach was used to validate base-case results. Results At mean follow-up of 2.7 years, CABG compared with PCI was associated with increased costs and greater all-cause mortality, but a significantly lower rate of MACCE. An ICER of $55,255 (Australian dollars)/MACCE avoided was observed for the overall cohort. The ICER varied across comparisons against bare metal stents (ICER $25,815/MACCE avoided), all drug-eluting stents (DES) ($56,861), second-generation DES ($42,925), and third-generation of DES ($88,535). Moderate-to-low ICERs were apparent for high-risk subgroups, including those with chronic kidney disease ($62,299), diabetes ($42,819), history of myocardial infarction ($30,431), left main coronary artery disease ($38,864), and heart failure ($36,966). Conclusions At early follow-up, high-risk subgroups had lower ICERs than the overall cohort when CABG was compared with PCI. A personalised, multidisciplinary approach to treatment of patients may enhance cost containment, as well as improving clinical outcomes following revascularisation strategies.

Suggested Citation

  • Thathya V. Ariyaratne & Zanfina Ademi & Molla Huq & Franklin Rosenfeldt & Stephen J. Duffy & Bonny Parkinson & Cheng-Hon Yap & Julian Smith & Baki Billah & Bryan P. Yan & Angela L. Brennan & Lavinia T, 2018. "The Real-World Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Stenting in High-Risk Patients: Propensity Score-Matched Analysis of a Single-Centre Experience," Applied Health Economics and Health Policy, Springer, vol. 16(5), pages 661-674, October.
  • Handle: RePEc:spr:aphecp:v:16:y:2018:i:5:d:10.1007_s40258-018-0407-5
    DOI: 10.1007/s40258-018-0407-5

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    References listed on IDEAS

    1. Glick, Henry A. & Doshi, Jalpa A. & Sonnad, Seema S. & Polsky, Daniel, 2014. "Economic Evaluation in Clinical Trials," OUP Catalogue, Oxford University Press, edition 2, number 9780199685028, Decembrie.
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