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Exploring the Relationship between Quality of Life (EQ-5D) and Clinical Measures in Adult Attention Deficit Hyperactivity Disorder (ADHD)

Author

Listed:
  • Attila J. Pulay

    (Semmelweis University)

  • István Bitter

    (Semmelweis University)

  • Szilvia Papp

    (Semmelweis University)

  • László Gulácsi

    (Corvinus University of Budapest)

  • Márta Péntek

    (Corvinus University of Budapest
    Flór Ferenc County Hospital)

  • Valentin Brodszky

    (Corvinus University of Budapest)

  • Noémi V. Hevér

    (Semmelweis University)

  • Fanni Rencz

    (Corvinus University of Budapest
    Semmelweis University Doctoral School of Clinical Medicine)

  • Petra Baji

    (Corvinus University of Budapest
    CERGE-EI Fellow)

Abstract

Objective To explore the association between quality of life (QoL) and clinical measures in patients with adult Attention Deficit Hyperactivity Disorder (ADHD); as well as assess the work impairment related to the disease. Method A cross-sectional study was conducted in an outpatient clinic of a university hospital in Hungary between 2011–2013 (n = 75). QoL was measured by the European Quality of Life-5 Dimensions questionnaire (EQ-5D). Associations between EQ-5D and clinical measures such as physician’s assessment on a visual analogue scale (physician-VAS), Clinical Global Impression-Severity scale (CGI-S), and Conners’ Adult ADHD Rating Scale (CAARS) subscores were assessed by Spearman-correlation and linear regression models. Productivity loss was estimated using the Work Productivity and Activity Impairment Questionnaire (WPAI) questionnaire. Results The mean EQ-5D index and EQ VAS scores were 0.74(SD = 0.22) and 69.5(SD = 19.4), significantly lower than the scores of the age-matched general population. Significant correlations were found between EQ-5D index and clinical measures. No correlation was found between CAARS and physician-VAS, CGI-S. The regression models explained 44.0 % of the EQ-5D index variance. The productivity loss was estimated to 47.5 %. Conclusion To our knowledge, this study is the first to analyze the relationship between EQ-5D and clinical measures in adult ADHD in real world practice. Significant correlation between EQ-5D and the clinical measures suggests that EQ-5D is a sensitive measure of the health impairment related to ADHD and psychiatric co-morbidities, thus it contributes to a better understanding of the burden of adult ADHD. The lack of association between the CAARS and physicians’ measures requires further research.

Suggested Citation

  • Attila J. Pulay & István Bitter & Szilvia Papp & László Gulácsi & Márta Péntek & Valentin Brodszky & Noémi V. Hevér & Fanni Rencz & Petra Baji, 2017. "Exploring the Relationship between Quality of Life (EQ-5D) and Clinical Measures in Adult Attention Deficit Hyperactivity Disorder (ADHD)," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 12(2), pages 409-424, June.
    • Handle: RePEc:spr:ariqol:v:12:y:2017:i:2:d:10.1007_s11482-016-9467-6
    DOI: 10.1007/s11482-016-9467-6
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    References listed on IDEAS

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    1. Mandel Michael & Anita Bálint & Barbara Lovász & László Gulácsi & Bálint Strbák & Petra Golovics & Klaudia Farkas & Zsuzsanna Kürti & Blanka Szilágyi & Anna Mohás & Tamás Molnár & Péter Lakatos, 2014. "Work disability and productivity loss in patients with inflammatory bowel diseases in Hungary in the era of biologics," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 15(1), pages 121-128, May.
    2. Emese Herédi & Fanni Rencz & Orsolya Balogh & László Gulácsi & Krisztina Herszényi & Péter Holló & Hajnalka Jókai & Sarolta Kárpáti & Márta Péntek & Éva Remenyik & Andrea Szegedi & Valentin Brodszky, 2014. "Exploring the relationship between EQ-5D, DLQI and PASI, and mapping EQ-5D utilities: a cross-sectional study in psoriasis from Hungary," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 15(1), pages 111-119, May.
    3. Michael Mandel & Anita Bálint & Barbara Lovász & László Gulácsi & Bálint Strbák & Petra Golovics & Klaudia Farkas & Zsuzsanna Kürti & Blanka Szilágyi & Anna Mohás & Tamás Molnár & Péter Lakatos, 2014. "Erratum to: Work disability and productivity loss in patients with inflammatory bowel diseases in Hungary in the era of biologics," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 15(1), pages 129-129, May.
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