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Polyadic synapses introduce unique wiring architectures in T5 cells of Drosophila

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  • Eleni Samara
  • Alexander Borst

Abstract

Connectomes provide neuronal wiring diagrams and allow for investigating the detailed synaptic morphology of each connection. In the visual system of Drosophila, T5 cells are the primary motion-sensing neurons in the OFF-pathway and receive dendritic input from the excitatory Tm1, Tm2, Tm4, Tm9 and the inhibitory CT1 neurons. This connectivity, however, has not yet been investigated with respect to polyadic synapses known to be abundant in the fly nervous system. In this study, we use the FlyWire database and identify that Tm and CT1 cells wire on T5a dendrites via eight polyadic synapse types. We then explore the distribution of the different synapse types on T5a dendrites and find differences in their spatial patterns. Finally, we show that the polyadic morphology is setting a directional wiring architecture at the T5 network level. Our work showcases the directionality that polyadic synapses introduce in T5 connectivity.

Suggested Citation

  • Eleni Samara & Alexander Borst, 2025. "Polyadic synapses introduce unique wiring architectures in T5 cells of Drosophila," PLOS ONE, Public Library of Science, vol. 20(10), pages 1-12, October.
    • Handle: RePEc:plo:pone00:0334925
    DOI: 10.1371/journal.pone.0334925
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    1. Philipp Schlegel & Yijie Yin & Alexander S. Bates & Sven Dorkenwald & Katharina Eichler & Paul Brooks & Daniel S. Han & Marina Gkantia & Marcia Santos & Eva J. Munnelly & Griffin Badalamente & Laia Se, 2024. "Whole-brain annotation and multi-connectome cell typing of Drosophila," Nature, Nature, vol. 634(8032), pages 139-152, October.
    2. Sven Dorkenwald & Arie Matsliah & Amy R. Sterling & Philipp Schlegel & Szi-chieh Yu & Claire E. McKellar & Albert Lin & Marta Costa & Katharina Eichler & Yijie Yin & Will Silversmith & Casey Schneider, 2024. "Neuronal wiring diagram of an adult brain," Nature, Nature, vol. 634(8032), pages 124-138, October.
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