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The coming wave of confluent biosynthetic, bioinformational and bioengineering technologies

Author

Listed:
  • Isak S. Pretorius

    (ARC Centre of Excellence in Synthetic Biology, Macquarie University)

  • Thomas A. Dixon

    (ARC Centre of Excellence in Synthetic Biology, Macquarie University)

  • Michael Boers

    (Macquarie University)

  • Ian T. Paulsen

    (ARC Centre of Excellence in Synthetic Biology, Macquarie University)

  • Daniel L. Johnson

    (ARC Centre of Excellence in Synthetic Biology, Macquarie University)

Abstract

Information and energy flows form the basis of all economic activity, with advanced technologies underpinning both. Profound uncertainties caused by geostrategic forces have accelerated a trillion-dollar race for technological superiority. The result is an onrush of “technovation” at the nexus of synthetic biotechnologies, information technologies, nanotechnologies and engineering technologies. This article explores recent breakthroughs in integrating chip technologies and synthetic bioinformational engineering. It investigates prospects of biomolecules as carriers of stored digital data, synthetic cells-on-a-chip, and hybrid semiconductors and next-generation artificial intelligence processors. Consilience—unity of knowledge—redefines possibilities emerging from the living interface of biologically-inspired engineering and engineering-enabled biology.

Suggested Citation

  • Isak S. Pretorius & Thomas A. Dixon & Michael Boers & Ian T. Paulsen & Daniel L. Johnson, 2025. "The coming wave of confluent biosynthetic, bioinformational and bioengineering technologies," Nature Communications, Nature, vol. 16(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58030-y
    DOI: 10.1038/s41467-025-58030-y
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    as
    1. Joseph L. Watson & David Juergens & Nathaniel R. Bennett & Brian L. Trippe & Jason Yim & Helen E. Eisenach & Woody Ahern & Andrew J. Borst & Robert J. Ragotte & Lukas F. Milles & Basile I. M. Wicky & , 2023. "De novo design of protein structure and function with RFdiffusion," Nature, Nature, vol. 620(7976), pages 1089-1100, August.
    2. Kathryn Tunyasuvunakool & Jonas Adler & Zachary Wu & Tim Green & Michal Zielinski & Augustin Žídek & Alex Bridgland & Andrew Cowie & Clemens Meyer & Agata Laydon & Sameer Velankar & Gerard J. Kleywegt, 2021. "Highly accurate protein structure prediction for the human proteome," Nature, Nature, vol. 596(7873), pages 590-596, August.
    3. Briardo Llorente & Thomas C. Williams & Hugh D. Goold & Isak S. Pretorius & Ian T. Paulsen, 2022. "Harnessing bioengineered microbes as a versatile platform for space nutrition," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    4. Neha Sapkal & Nino Mancini & Divya Sthanu Kumar & Nico Spiller & Kazuma Murakami & Gianna Vitelli & Benjamin Bargeron & Kate Maier & Katharina Eichler & Gregory S. X. E. Jefferis & Philip K. Shiu & Ga, 2024. "Neural circuit mechanisms underlying context-specific halting in Drosophila," Nature, Nature, vol. 634(8032), pages 191-200, October.
    5. Nick Goldman & Paul Bertone & Siyuan Chen & Christophe Dessimoz & Emily M. LeProust & Botond Sipos & Ewan Birney, 2013. "Towards practical, high-capacity, low-maintenance information storage in synthesized DNA," Nature, Nature, vol. 494(7435), pages 77-80, February.
    6. Philip K. Shiu & Gabriella R. Sterne & Nico Spiller & Romain Franconville & Andrea Sandoval & Joie Zhou & Neha Simha & Chan Hyuk Kang & Seongbong Yu & Jinseop S. Kim & Sven Dorkenwald & Arie Matsliah , 2024. "A Drosophila computational brain model reveals sensorimotor processing," Nature, Nature, vol. 634(8032), pages 210-219, October.
    7. Tae Seok Moon & Chunbo Lou & Alvin Tamsir & Brynne C. Stanton & Christopher A. Voigt, 2012. "Genetic programs constructed from layered logic gates in single cells," Nature, Nature, vol. 491(7423), pages 249-253, November.
    8. Susana Vázquez Torres & Philip J. Y. Leung & Preetham Venkatesh & Isaac D. Lutz & Fabian Hink & Huu-Hien Huynh & Jessica Becker & Andy Hsien-Wei Yeh & David Juergens & Nathaniel R. Bennett & Andrew N., 2024. "De novo design of high-affinity binders of bioactive helical peptides," Nature, Nature, vol. 626(7998), pages 435-442, February.
    9. John Jumper & Richard Evans & Alexander Pritzel & Tim Green & Michael Figurnov & Olaf Ronneberger & Kathryn Tunyasuvunakool & Russ Bates & Augustin Žídek & Anna Potapenko & Alex Bridgland & Clemens Me, 2021. "Highly accurate protein structure prediction with AlphaFold," Nature, Nature, vol. 596(7873), pages 583-589, August.
    10. Xin Xu & Felix Meier & Benjamin A. Blount & Isak S. Pretorius & Tom Ellis & Ian T. Paulsen & Thomas C. Williams, 2023. "Trimming the genomic fat: minimising and re-functionalising genomes using synthetic biology," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    11. Philipp Schlegel & Yijie Yin & Alexander S. Bates & Sven Dorkenwald & Katharina Eichler & Paul Brooks & Daniel S. Han & Marina Gkantia & Marcia Santos & Eva J. Munnelly & Griffin Badalamente & Laia Se, 2024. "Whole-brain annotation and multi-connectome cell typing of Drosophila," Nature, Nature, vol. 634(8032), pages 139-152, October.
    12. Thomas A. Dixon & Thomas C. Williams & Isak S. Pretorius, 2021. "Sensing the future of bio-informational engineering," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    13. Alvin Tamsir & Jeffrey J. Tabor & Christopher A. Voigt, 2011. "Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’," Nature, Nature, vol. 469(7329), pages 212-215, January.
    14. Lifu Song & Feng Geng & Zi-Yi Gong & Xin Chen & Jijun Tang & Chunye Gong & Libang Zhou & Rui Xia & Ming-Zhe Han & Jing-Yi Xu & Bing-Zhi Li & Ying-Jin Yuan, 2022. "Robust data storage in DNA by de Bruijn graph-based de novo strand assembly," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    15. Sven Dorkenwald & Arie Matsliah & Amy R. Sterling & Philipp Schlegel & Szi-chieh Yu & Claire E. McKellar & Albert Lin & Marta Costa & Katharina Eichler & Yijie Yin & Will Silversmith & Casey Schneider, 2024. "Neuronal wiring diagram of an adult brain," Nature, Nature, vol. 634(8032), pages 124-138, October.
    16. Cheng Zhang & Ranfeng Wu & Fajia Sun & Yisheng Lin & Yuan Liang & Jiongjiong Teng & Na Liu & Qi Ouyang & Long Qian & Hao Yan, 2024. "Parallel molecular data storage by printing epigenetic bits on DNA," Nature, Nature, vol. 634(8035), pages 824-832, October.
    17. Jonathan Symons & Thomas A. Dixon & Jacqueline Dalziell & Natalie Curach & Ian T. Paulsen & Anthony Wiskich & Isak S. Pretorius, 2024. "Engineering biology and climate change mitigation: Policy considerations," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    18. Thomas A. Dixon & Paul S. Freemont & Richard A. Johnson & Isak S. Pretorius, 2022. "A global forum on synthetic biology: the need for international engagement," Nature Communications, Nature, vol. 13(1), pages 1-5, December.
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