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Uric acid levels and risk of cognitive impairment: Dose-response meta-analysis of prospective cohort studies

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  • Qianqian Liu
  • Min Peng
  • Tiantian Yang
  • Guomin Si

Abstract

Purpose: Studying the effects of uric acid levels on cognitive function and quantifying the dose-response relationship. Methods: Based on PubMed and Embase search terms, we identified prospective cohort studies that included blood uric acid as a risk factor and cognitive impairment as a result up to September 2022. We extracted pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs). Results: Nine reports (including 488,915 participants and 5516 cognitive impairment cases) with median follow-up of 8.8–22 years were eligible for analyses. Compared with lowest category of blood uric acid concentration, the combined RR of cognitive impairment events in the highest classification was 0.81 (95% CI: 0.70–0.92, P

Suggested Citation

  • Qianqian Liu & Min Peng & Tiantian Yang & Guomin Si, 2023. "Uric acid levels and risk of cognitive impairment: Dose-response meta-analysis of prospective cohort studies," PLOS ONE, Public Library of Science, vol. 18(11), pages 1-20, November.
    • Handle: RePEc:plo:pone00:0293832
    DOI: 10.1371/journal.pone.0293832
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