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The Targeted Maximum Likelihood estimation to estimate the causal effects of the previous tuberculosis treatment in Multidrug-resistant tuberculosis in Sudan

Author

Listed:
  • Adel Hussein Elduma
  • Kourosh Holakouie-Naieni
  • Amir Almasi-Hashiani
  • Abbas Rahimi Foroushani
  • Hamdan Mustafa Hamdan Ali
  • Muatsim Ahmed Mohammed Adam
  • Asma Elsony
  • Mohammad Ali Mansournia

Abstract

Introduction: This study used Targeted Maximum Likelihood Estimation (TMLE) as a double robust method to estimate the causal effect of previous tuberculosis treatment history on the occurrence of multidrug-resistant tuberculosis (MDR-TB). TMLE is a method to estimate the marginal statistical parameters in case-control study design. The aim of this study was to estimate the causal effect of the previous tuberculosis treatment on the occurrence of MDR-TB using TMLE in Sudan. Method: A case-control study design combined with TMLE was used to estimate parameters. Cases were MDR-TB patients and controls were and patients who cured from tuberculosis. The history of previous TB treatment was considered the main exposure, and MDR-TB as an outcome. A designed questionnaire was used to collect a set of covariates including age, time to reach a health facility, number of times stopping treatment, gender, education level, and contact with MDR-TB cases. TMLE method was used to estimate the causal association of parameters. Statistical analysis was carried out with ltmle package in R-software. Result presented in graph and tables. Results: A total number of 430 cases and 860 controls were included in this study. The estimated risk difference of the previous tuberculosis treatment was (0.189, 95% CI; 0.161, 0.218) with SE 0.014, and p-value (

Suggested Citation

  • Adel Hussein Elduma & Kourosh Holakouie-Naieni & Amir Almasi-Hashiani & Abbas Rahimi Foroushani & Hamdan Mustafa Hamdan Ali & Muatsim Ahmed Mohammed Adam & Asma Elsony & Mohammad Ali Mansournia, 2023. "The Targeted Maximum Likelihood estimation to estimate the causal effects of the previous tuberculosis treatment in Multidrug-resistant tuberculosis in Sudan," PLOS ONE, Public Library of Science, vol. 18(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0279976
    DOI: 10.1371/journal.pone.0279976
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    References listed on IDEAS

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    1. van der Laan Mark J. & Gruber Susan, 2012. "Targeted Minimum Loss Based Estimation of Causal Effects of Multiple Time Point Interventions," The International Journal of Biostatistics, De Gruyter, vol. 8(1), pages 1-41, May.
    2. van der Laan Mark J., 2008. "Estimation Based on Case-Control Designs with Known Prevalence Probability," The International Journal of Biostatistics, De Gruyter, vol. 4(1), pages 1-59, September.
    3. Gruber Susan & van der Laan Mark J., 2012. "Targeted Minimum Loss Based Estimation of a Causal Effect on an Outcome with Known Conditional Bounds," The International Journal of Biostatistics, De Gruyter, vol. 8(1), pages 1-18, July.
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    1. Temesgen Yihunie Akalu & Archie C A Clements & Adhanom Gebreegziabher Baraki & Kefyalew Addis Alene, 2023. "Protocol for a systematic review of long-term physical sequelae and financial burden of multidrug-resistant and extensively drug-resistant tuberculosis," PLOS ONE, Public Library of Science, vol. 18(5), pages 1-7, May.

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