IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0178404.html
   My bibliography  Save this article

Plasma levels of high-mobility group box 1 and soluble receptor for advanced glycation end products in primary antiphospholipid antibody syndrome patients

Author

Listed:
  • Kuo-Tung Tang
  • Tsu-Yi Hsieh
  • Ya-Hsuan Chao
  • Meng-Xian Lin
  • Yi-Hsing Chen
  • Der-Yuan Chen
  • Chi-Chen Lin

Abstract

Introduction: Many studies have demonstrated elevated circulating levels of high-mobility group box 1 (HMGB1) and decreased circulating levels of soluble receptor for advanced glycation end products (sRAGE) in patients with autoimmune diseases. In the present study, we investigated plasma levels of both HMGB1 and sRAGE in primary antiphospholipid syndrome (pAPS) patients. Methods: We prospectively recruited 11 pAPS patients, 17 antiphospholipid antibody (APA)-positive SLE patients without APS manifestations (APA+SLE) and 12 SLE patients with secondary APS (APS+SLE). We also recruited 10 healthy controls (HCs). Plasma levels of HMGB1 and sRAGE were determined using sandwich ELISA kits. In addition, plasma levels of HMGB1 were also determined using Western blot in 6 pAPS patients and 6 HCs. Results: There was no significant difference in plasma levels of HMGB1 measured by ELISA among subgroups of the enrolled subjects. In addition, there was no significant difference in plasma levels of HMGB1 measured by Western blot between pAPS patients and HCs. On the other hand, we observed a trend toward lower plasma levels of sRAGE in APA+SLE or APS+SLE patients when compared with HCs. However, there was no significant difference in plasma levels of sRAGE between pAPS patients and HCs, or between APA+SLE patients and APS+SLE patients. Conclusion: There was no significant difference in plasma levels of sRAGE or HMGB1 between pAPS patients and HCs. Plasma levels of sRAGE/HMGB1 could not be utilized to differentiate between APA+SLE and APS+SLE patients.

Suggested Citation

  • Kuo-Tung Tang & Tsu-Yi Hsieh & Ya-Hsuan Chao & Meng-Xian Lin & Yi-Hsing Chen & Der-Yuan Chen & Chi-Chen Lin, 2017. "Plasma levels of high-mobility group box 1 and soluble receptor for advanced glycation end products in primary antiphospholipid antibody syndrome patients," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0178404
    DOI: 10.1371/journal.pone.0178404
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178404
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178404&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0178404?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Paola Scaffidi & Tom Misteli & Marco E. Bianchi, 2002. "Release of chromatin protein HMGB1 by necrotic cells triggers inflammation," Nature, Nature, vol. 418(6894), pages 191-195, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Meihua Jin & Hiroki Shiwaku & Hikari Tanaka & Takayuki Obita & Sakurako Ohuchi & Yuki Yoshioka & Xiaocen Jin & Kanoh Kondo & Kyota Fujita & Hidenori Homma & Kazuyuki Nakajima & Mineyuki Mizuguchi & Hi, 2021. "Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation," Nature Communications, Nature, vol. 12(1), pages 1-22, December.
    2. Wan-Ru Zhuang & Yunfeng Wang & Weidong Nie & Yao Lei & Chao Liang & Jiaqi He & Liping Zuo & Li-Li Huang & Hai-Yan Xie, 2023. "Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Lu Zhang & Jianjun Han & Huiyong Wu & Xiaohong Liang & Jianxin Zhang & Jian Li & Li Xie & Yinfa Xie & Xiugui Sheng & Jinming Yu, 2014. "The Association of HMGB1 Expression with Clinicopathological Significance and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis and Literature Review," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.
    4. Malisa Vittoria Mantonico & Federica Leo & Giacomo Quilici & Liam Sean Colley & Francesco Marchis & Massimo Crippa & Rosanna Mezzapelle & Tim Schulte & Chiara Zucchelli & Chiara Pastorello & Camilla C, 2024. "The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0178404. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.