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The Association of HMGB1 Expression with Clinicopathological Significance and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis and Literature Review

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  • Lu Zhang
  • Jianjun Han
  • Huiyong Wu
  • Xiaohong Liang
  • Jianxin Zhang
  • Jian Li
  • Li Xie
  • Yinfa Xie
  • Xiugui Sheng
  • Jinming Yu

Abstract

Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer, and it is the second most common cancer-related mortality globally. The prognostic value of high mobility group box 1 (HMGB1) remains controversial. The purpose of this study is to conduct a meta-analysis and literature review to evaluate the association of HMGB1 expression with the prognosis of patients with HCC. Methods: A detailed literature search was made in Medline, Google Scholar and others for related research publications. The data were extracted and assessed by two reviewers independently. Analysis of pooled data were performed, Hazard Ratio (HR) and mean difference with corresponding confidence intervals (CIs) were calculated and summarized respectively. Results: 10 relevant articles were included for this meta-analysis study. HMGB1 mRNA levels in HCC were significantly higher than those in normal (p

Suggested Citation

  • Lu Zhang & Jianjun Han & Huiyong Wu & Xiaohong Liang & Jianxin Zhang & Jian Li & Li Xie & Yinfa Xie & Xiugui Sheng & Jinming Yu, 2014. "The Association of HMGB1 Expression with Clinicopathological Significance and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis and Literature Review," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0110626
    DOI: 10.1371/journal.pone.0110626
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    1. Paola Scaffidi & Tom Misteli & Marco E. Bianchi, 2002. "Release of chromatin protein HMGB1 by necrotic cells triggers inflammation," Nature, Nature, vol. 418(6894), pages 191-195, July.
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