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Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory

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  • Dominique Girard
  • Jean-Claude Tardif
  • Julie Boisclair Demarble
  • Bianca D’Antono

Abstract

Hostility has been associated with higher basal levels of inflammation. The present study evaluated the association of hostility with acute stress-induced changes in inflammatory activity. One hundred and ninety-nine healthy men and women, aged 19–64 years, were exposed to a stress protocol involving four interpersonal stressors. Participants completed the Cook-Medley Hostility questionnaire and provided two blood samples for the measurement of inflammatory biomarkers (CRP, Il-6, MPO, TNF-α, MCP-1, Il-8, Il-10, and Il-18), prior to and following exposure to a standardized stress protocol. In univariate analyses, hostility was associated with significantly higher TNF-α, but lower Il-8 and Il-18 values post-stress, though only Il-8 remained significant after controlling for baseline differences. In multivariate analyses, a significant Age by Hostility interaction emerged for Il-6, while sex moderated the relation between hostility and Il-10 reactivity. Following stress, hostility was associated with greater pro-inflammatory Il-6 activity among younger individuals and to decreased anti-inflammatory Il-10 activity in women. Future research is needed to replicate these findings and to evaluate their implication for disease.

Suggested Citation

  • Dominique Girard & Jean-Claude Tardif & Julie Boisclair Demarble & Bianca D’Antono, 2016. "Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-19, June.
    • Handle: RePEc:plo:pone00:0156329
    DOI: 10.1371/journal.pone.0156329
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    References listed on IDEAS

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    1. Yang, Yang Claire & Schorpp, Kristen & Harris, Kathleen Mullan, 2014. "Social support, social strain and inflammation: Evidence from a national longitudinal study of U.S. adults," Social Science & Medicine, Elsevier, vol. 107(C), pages 124-135.
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