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Investigation of Genetic Variation Underlying Central Obesity amongst South Asians

Author

Listed:
  • William R Scott
  • Weihua Zhang
  • Marie Loh
  • Sian-Tsung Tan
  • Benjamin Lehne
  • Uzma Afzal
  • Juan Peralta
  • Richa Saxena
  • Sarju Ralhan
  • Gurpreet S Wander
  • Kiymet Bozaoglu
  • Dharambir K Sanghera
  • Paul Elliott
  • James Scott
  • John C Chambers
  • Jaspal S Kooner

Abstract

South Asians are 1/4 of the world’s population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on genome-wide association studies of common SNPs in Europeans. To evaluate the contribution of DNA sequence variation to the higher levels of central obesity (defined as waist hip ratio adjusted for body mass index, WHR) among South Asians compared to Europeans we carried out: i) a genome-wide association analysis of >6M genetic variants in 10,318 South Asians with focused analysis of population-specific SNPs; ii) an exome-wide association analysis of ~250K SNPs in protein-coding regions in 2,637 South Asians; iii) a comparison of risk allele frequencies and effect sizes of 48 known WHR SNPs in 12,240 South Asians compared to Europeans. In genome-wide analyses, we found no novel associations between common genetic variants and WHR in South Asians at P

Suggested Citation

  • William R Scott & Weihua Zhang & Marie Loh & Sian-Tsung Tan & Benjamin Lehne & Uzma Afzal & Juan Peralta & Richa Saxena & Sarju Ralhan & Gurpreet S Wander & Kiymet Bozaoglu & Dharambir K Sanghera & Pa, 2016. "Investigation of Genetic Variation Underlying Central Obesity amongst South Asians," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-17, May.
    • Handle: RePEc:plo:pone00:0155478
    DOI: 10.1371/journal.pone.0155478
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    References listed on IDEAS

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