IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0155478.html
   My bibliography  Save this article

Investigation of Genetic Variation Underlying Central Obesity amongst South Asians

Author

Listed:
  • William R Scott
  • Weihua Zhang
  • Marie Loh
  • Sian-Tsung Tan
  • Benjamin Lehne
  • Uzma Afzal
  • Juan Peralta
  • Richa Saxena
  • Sarju Ralhan
  • Gurpreet S Wander
  • Kiymet Bozaoglu
  • Dharambir K Sanghera
  • Paul Elliott
  • James Scott
  • John C Chambers
  • Jaspal S Kooner

Abstract

South Asians are 1/4 of the world’s population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on genome-wide association studies of common SNPs in Europeans. To evaluate the contribution of DNA sequence variation to the higher levels of central obesity (defined as waist hip ratio adjusted for body mass index, WHR) among South Asians compared to Europeans we carried out: i) a genome-wide association analysis of >6M genetic variants in 10,318 South Asians with focused analysis of population-specific SNPs; ii) an exome-wide association analysis of ~250K SNPs in protein-coding regions in 2,637 South Asians; iii) a comparison of risk allele frequencies and effect sizes of 48 known WHR SNPs in 12,240 South Asians compared to Europeans. In genome-wide analyses, we found no novel associations between common genetic variants and WHR in South Asians at P

Suggested Citation

  • William R Scott & Weihua Zhang & Marie Loh & Sian-Tsung Tan & Benjamin Lehne & Uzma Afzal & Juan Peralta & Richa Saxena & Sarju Ralhan & Gurpreet S Wander & Kiymet Bozaoglu & Dharambir K Sanghera & Pa, 2016. "Investigation of Genetic Variation Underlying Central Obesity amongst South Asians," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-17, May.
    • Handle: RePEc:plo:pone00:0155478
    DOI: 10.1371/journal.pone.0155478
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155478
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155478&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0155478?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0155478. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.