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Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer

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  • Hong Chen
  • Lin Ge
  • Qiuli Sui
  • Mei Lin

Abstract

Aim: To evaluate the association between the EPHX1 Tyr113His and His139Arg polymorphisms in the EPHX1 gene and the risk of head and neck cancer. Materials and Methods: Studies on the association of EPHX1 Tyr113His and His139Arg polymorphisms with HNC performed up until June 1st, 2014, were identified using a predefined search strategy. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of these associations. Results: In this meta-analysis, 10 case-control studies, which included 9 studies of Tyr113His (1890 cases and 1894 controls) and 10 studies of His139Arg polymorphisms (1982 cases and 2024 controls), were considered eligible for inclusion. Overall, the pooled results indicated that the EPHX1 Tyr113His polymorphism was significantly associated with increased HNC risk (Tyr/His vs. Tyr/Tyr, OR = 1.26, 95%1.02–1.57;His/His+ Tyr/His vs. Tyr/Tyr, OR = 1.29, 95% I = 1.03–1.61). However, no significant association was found between the His139Arg polymorphism and HNC risk. In the subgroup analysis, a statistically significant association between the EPHX1 Tyr113His polymorphism and HNC was observed in population-based case-control studies (PCC), which involved less than 500 participants and genotype frequencies in HWE. This association showed minimal heterogeneity after excluding studies that were determined to contribute to heterogeneity. After categorizing the studies by publication time, a sensitivity analysis and cumulative meta-analysis of the two associations were conducted, and the results of the two analyses were consistent. Conclusion: Our meta-analysis suggests that EPHX1 Tyr113His polymorphism may be a risk factor for HNC, while the EPHX1 His139Arg polymorphism has no association with HNC risk.

Suggested Citation

  • Hong Chen & Lin Ge & Qiuli Sui & Mei Lin, 2015. "Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0123347
    DOI: 10.1371/journal.pone.0123347
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    1. Jian-Hong Zhong & Bang-De Xiang & Liang Ma & Xue-Mei You & Le-Qun Li & Gui-Sheng Xie, 2013. "Meta-Analysis of Microsomal Epoxide Hydrolase Gene Polymorphism and Risk of Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.
    2. Jan H. J. Hoeijmakers, 2001. "Genome maintenance mechanisms for preventing cancer," Nature, Nature, vol. 411(6835), pages 366-374, May.
    3. Fei Liu & Ding Yuan & Yonggang Wei & Wentao Wang & Lvnan Yan & Tianfu Wen & Mingqing Xu & Jiayin Yang & Bo Li, 2012. "Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and Colorectal Cancer Risk," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.
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