IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0083710.html
   My bibliography  Save this article

Association between CTLA-4 60G/A and -1661A/G Polymorphisms and the Risk of Cancers: A Meta-Analysis

Author

Listed:
  • Qing Yan
  • Pin Chen
  • Ailin Lu
  • Peng Zhao
  • Aihua Gu

Abstract

Purpose: CTLA-4 is one of the most fundamental immunosuppressive cotykines which belongs to the immunoglobulin super-family, and is expressed mainly on activated T cells. Previous studies have reported the existence of CTLA4 60G/A and CTLA4 -1661A/G polymorphism in cancers. However, the effects remain conflicting. Hence, we performed a meta-analysis to investigate the association between these polymorphisms and cancer risk. Methods: We searched the Pubmed and Web of Science databases until October 24, 2013 to obtain relevant published studies. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the relationship between CTLA4 gene polymorphisms and cancer susceptibility were calculated by stata 11 software. Heterogeneity tests, sensitivity analyses and publication bias assessments were also performed in our meta-analysis. Results: A total of 22 articles comprising 31 case-control studies concerning the CTLA-4 60G/A and CTLA-4 -1661A/G polymorphisms were included in the meta-analysis. The pooled results suggested the CTLA-4 60G/A polymorphism was significantly associated with an increased skin cancer risk (AA vs. GG: OR = 1.32, 95%CI = 1.09-1.59; AA vs. GA+GG: OR = 1.26, 95%CI = 1.07-1.48). For CTLA-4 -1661 A/G polymorphism, the results showed that the CTLA-4 -1661A/G polymorphism was significantly associated with an increased cancer risk (GA vs. AA: OR = 1.44, 95%CI = 1.13–1.82; GA+GG vs. AA: OR = 1.35, 95%CI = 1.07–1.69; G vs. A: OR = 1.21, 95%CI = 1.01–1.47), especially in gastric cancer, breast cancer, other cancers and in Asians population subgroups. Conclusion: Our meta-analysis suggests that the CTLA-4 -1661A/G polymorphism is a potential factor for the susceptibility of cancer, especially in gastric cancer, breast cancer and other cancers, and the CTLA-4 60G/A polymorphism is significantly associated with increased skin cancer risk. The effect of the CTLA-4 -1661A/G polymorphism on cancer susceptibility especially exists in Asians and population based subjects.

Suggested Citation

  • Qing Yan & Pin Chen & Ailin Lu & Peng Zhao & Aihua Gu, 2013. "Association between CTLA-4 60G/A and -1661A/G Polymorphisms and the Risk of Cancers: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-9, December.
  • Handle: RePEc:plo:pone00:0083710
    DOI: 10.1371/journal.pone.0083710
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083710
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0083710&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0083710?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jan H. J. Hoeijmakers, 2001. "Genome maintenance mechanisms for preventing cancer," Nature, Nature, vol. 411(6835), pages 366-374, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Blasi, Monica Francesca & Casorelli, Ida & Colosimo, Alfredo & Blasi, Francesco Simone & Bignami, Margherita & Giuliani, Alessandro, 2005. "A recursive network approach can identify constitutive regulatory circuits in gene expression data," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 348(C), pages 349-370.
    2. Yong-qiang Wang & Xiao-wei Qi & Fan Wang & Jun Jiang & Qiao-nan Guo, 2012. "Association between TGFBR1 Polymorphisms and Cancer Risk: A Meta-Analysis of 35 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.
    3. Mengmeng Zhao & Pin Chen & Yanbin Dong & Xianji Zhu & Xilong Zhang, 2014. "Relationship between Rad51 G135C and G172T Variants and the Susceptibility to Cancer: A Meta-Analysis Involving 54 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
    4. Hongtuan Zhang & Hui Ma & Liang Li & Zhihong Zhang & Yong Xu, 2013. "Association of Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms with Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-7, July.
    5. Rui-Xi Hua & He-Ping Li & Yan-Bing Liang & Jin-Hong Zhu & Bing Zhang & Sheng Ye & Qiang-Sheng Dai & Shi-Qiu Xiong & Yong Gu & Xiang-Zhou Sun, 2014. "Association between the PARP1 Val762Ala Polymorphism and Cancer Risk: Evidence from 43 Studies," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.
    6. Qin Qin & Jing Lu & Hongcheng Zhu & Liping Xu & Hongyan Cheng & Liangliang Zhan & Xi Yang & Chi Zhang & Xinchen Sun, 2014. "PARP-1 Val762Ala Polymorphism and Risk of Cancer: A Meta-Analysis Based on 39 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-12, May.
    7. Yin Lou & Wen-jia Peng & Dong-sheng Cao & Juan Xie & Hong-hong Li & Zheng-xuan Jiang, 2013. "DNA Repair Gene XRCC1 Polymorphisms and Head and Neck Cancer Risk: An Updated Meta-Analysis Including 16344 Subjects," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    8. Simão, Éder M. & Cabral, Heleno B. & Castro, Mauro A.A. & Sinigaglia, Marialva & Mombach, José C.M. & Librelotto, Giovani R., 2010. "Modeling the Human Genome Maintenance network," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 389(19), pages 4188-4194.
    9. Ronan Broderick & Sivaramakrishnan Ramadurai & Katalin Tóth & Denisio M Togashi & Alan G Ryder & Jörg Langowski & Heinz Peter Nasheuer, 2012. "Cell Cycle-Dependent Mobility of Cdc45 Determined in vivo by Fluorescence Correlation Spectroscopy," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-10, April.
    10. Guohua Huang & Shaoxi Cai & Wei Wang & Qing Zhang & Aihua Liu, 2013. "Association between XRCC1 and XRCC3 Polymorphisms with Lung Cancer Risk: A Meta-Analysis from Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-13, August.
    11. Bian Wu & Hong-Li Liu & Sheng Zhang & Xiao-Rong Dong & Gang Wu, 2012. "Lack of an Association between Two BER Gene Polymorphisms and Breast Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    12. Tao Bu & Li Liu & Yong Sun & Li Zhao & Yang Peng & Shudong Zhou & Lixia Li & Sidong Chen & Yanhui Gao, 2014. "XRCC1 Arg399Gln Polymorphism Confers Risk of Breast Cancer in American Population: A Meta-Analysis of 10846 Cases and 11723 Controls," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.
    13. Hong Chen & Lin Ge & Qiuli Sui & Mei Lin, 2015. "Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-15, April.
    14. Peiliang Geng & Jianjun Li & Juanjuan Ou & Ganfeng Xie & Ning Wang & Lisha Xiang & Rina Sa & Chen Liu & Hongtao Li & Houjie Liang, 2014. "Association of Fas -1377 G/A Polymorphism with Susceptibility to Cancer," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0083710. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.