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Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer

Author

Listed:
  • Kim Wopken
  • Hendrik P Bijl
  • Arjen van der Schaaf
  • Miranda E Christianen
  • Olga Chouvalova
  • Sjoukje F Oosting
  • Bernard F A M van der Laan
  • Jan L N Roodenburg
  • C René Leemans
  • Ben J Slotman
  • Patricia Doornaert
  • Roel J H M Steenbakkers
  • Irma M Verdonck-de Leeuw
  • Johannes A Langendijk

Abstract

Background: Curative radiotherapy or chemoradiation for head and neck cancer (HNC) may result in severe acute and late side effects, including tube feeding dependence. Patients and Methods: Tube feeding dependence was scored prospectively. To develop the multivariable model, a group LASSO analysis was carried out, with TUBEM6 as the primary endpoint (n = 427). The model was then validated in a test cohort (n = 183). The training cohort was divided into three groups based on the risk of TUBEM6 to test whether the model could be extrapolated to later time points (12, 18 and 24 months). Results: Most important predictors for TUBEM6 were weight loss prior to treatment, advanced T-stage, positive N-stage, bilateral neck irradiation, accelerated radiotherapy and chemoradiation. Model performance was good, with an Area under the Curve of 0.86 in the training cohort and 0.82 in the test cohort. The TUBEM6-based risk groups were significantly associated with tube feeding dependence at later time points (p

Suggested Citation

  • Kim Wopken & Hendrik P Bijl & Arjen van der Schaaf & Miranda E Christianen & Olga Chouvalova & Sjoukje F Oosting & Bernard F A M van der Laan & Jan L N Roodenburg & C René Leemans & Ben J Slotman & Pa, 2014. "Development and Validation of a Prediction Model for Tube Feeding Dependence after Curative (Chemo-) Radiation in Head and Neck Cancer," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-8, April.
    • Handle: RePEc:plo:pone00:0094879
    DOI: 10.1371/journal.pone.0094879
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    1. Michael E. Miller & Carl D. Langefeld & William M. Tierney & Siu L. Hui & Clement J. McDonald, 1993. "Validation of Probabilistic Predictions," Medical Decision Making, , vol. 13(1), pages 49-57, February.
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