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Quantitative Assessment of Common Genetic Variants on FOXE1 and Differentiated Thyroid Cancer Risk

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  • Hongling Zhu
  • Qian Xi
  • Lianyong Liu
  • Jingnan Wang
  • Mingjun Gu

Abstract

Forkhead box E1 encodes the transcription factor FOXE1 (or TTF-2), which together with Homeobox protein NKX2-1, PAX8 and HHEX, are pivotal proteins required for thyroid gland formation, differentiation and function. Recently, genome-wide association studies have identified FOXE1 as a thyroid cancer (TC) susceptibility gene in populations of European descent. After that, a number of studies reported that the rs965513, rs1867277, and rs71369530 polymorphism in FOXE1 has been implicated in TC risk. However, the causal variants remain unknown. To derive a more precise estimation of the relationship, a meta-analysis of 9,828 TC cases and 109,995 controls from 14 case–control studies was performed. Overall, significant results were observed for rs965513 (OR = 1.71, 95% CI: 1.59–1.85, P

Suggested Citation

  • Hongling Zhu & Qian Xi & Lianyong Liu & Jingnan Wang & Mingjun Gu, 2014. "Quantitative Assessment of Common Genetic Variants on FOXE1 and Differentiated Thyroid Cancer Risk," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0087332
    DOI: 10.1371/journal.pone.0087332
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    1. Bo Zhou & Zhenshun Song & Mingping Qian & Liang Li & Jian Gong & Shaowu Zou, 2013. "Functional Polymorphisms in the CYP2C19 Gene Contribute to Digestive System Cancer Risk: Evidence from 11,042 Subjects," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-5, July.
    2. Sheng Wu & Jungang Cai & Hong Wang & Hongwei Zhang & Weige Yang, 2013. "Association between 1p11-rs11249433 Polymorphism and Breast Cancer Susceptibility: Evidence from 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
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