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Association between 1p11-rs11249433 Polymorphism and Breast Cancer Susceptibility: Evidence from 15 Case-Control Studies

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  • Sheng Wu
  • Jungang Cai
  • Hong Wang
  • Hongwei Zhang
  • Weige Yang

Abstract

Genome-wide association studies have identified SNP rs11249433 at chromosome 1p11 as a new breast cancer (BC) susceptibility locus in populations of European descent. Since then, the relationship between 1p11- rs11249433 and breast cancer has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency, we performed a meta-analysis of 15 studies involving a total of 90,154 cases and 137,238 controls for 1p11-rs11249433 polymorphism to evaluate its effect on genetic susceptibility for breast cancer. An overall random effects odds ratio of 1.09 (95% CI: 1.06-1.12, P

Suggested Citation

  • Sheng Wu & Jungang Cai & Hong Wang & Hongwei Zhang & Weige Yang, 2013. "Association between 1p11-rs11249433 Polymorphism and Breast Cancer Susceptibility: Evidence from 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    • Handle: RePEc:plo:pone00:0072526
    DOI: 10.1371/journal.pone.0072526
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    Cited by:

    1. Hongling Zhu & Qian Xi & Lianyong Liu & Jingnan Wang & Mingjun Gu, 2014. "Quantitative Assessment of Common Genetic Variants on FOXE1 and Differentiated Thyroid Cancer Risk," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.

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