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Functional Polymorphisms in the CYP2C19 Gene Contribute to Digestive System Cancer Risk: Evidence from 11,042 Subjects

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  • Bo Zhou
  • Zhenshun Song
  • Mingping Qian
  • Liang Li
  • Jian Gong
  • Shaowu Zou

Abstract

Background: CYP2C19 belongs to the cytochrome P450 superfamily of enzymes involved in activating and detoxifying many carcinogens and endogenous compounds, which has attracted considerable attention as a candidate gene for digestive system cancer. CYP2C19 has two main point mutation sites (CYP2C19*2, CYP2C19*3) leading to poor metabolizer (PM) phenotype. In the past decade, the relationship between CYP2C19 polymorphism and digestive system cancer has been reported in various ethnic groups; however, these studies have yielded contradictory results. Methods: To clarify this inconsistency, we performed this meta-analysis. Databases including Pubmed, EMBASE, Web of Science and China National Knowledge Infrastructure (CNKI) were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Results: In total, 18 studies with 4,414 cases and 6,628 controls were included. Overall, significantly elevated digestive system cancer risk was associated CYP2C19 PM with OR of 1.66 (95%CI: 1.31–2.10, P

Suggested Citation

  • Bo Zhou & Zhenshun Song & Mingping Qian & Liang Li & Jian Gong & Shaowu Zou, 2013. "Functional Polymorphisms in the CYP2C19 Gene Contribute to Digestive System Cancer Risk: Evidence from 11,042 Subjects," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-5, July.
    • Handle: RePEc:plo:pone00:0066865
    DOI: 10.1371/journal.pone.0066865
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    Cited by:

    1. Hongling Zhu & Qian Xi & Lianyong Liu & Jingnan Wang & Mingjun Gu, 2014. "Quantitative Assessment of Common Genetic Variants on FOXE1 and Differentiated Thyroid Cancer Risk," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.

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