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Meta-Analysis Identifies NF-κB as a Therapeutic Target in Renal Cancer

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  • Suraj Peri
  • Karthik Devarajan
  • Dong-Hua Yang
  • Alfred G Knudson
  • Siddharth Balachandran

Abstract

Objective: To determine the expression patterns of NF-κB regulators and target genes in clear cell renal cell carcinoma (ccRCC), their correlation with von Hippel Lindau (VHL) mutational status, and their association with survival outcomes. Methods: Meta-analyses were carried out on published ccRCC gene expression datasets by RankProd, a non-parametric statistical method. DEGs with a False Discovery Rate of

Suggested Citation

  • Suraj Peri & Karthik Devarajan & Dong-Hua Yang & Alfred G Knudson & Siddharth Balachandran, 2013. "Meta-Analysis Identifies NF-κB as a Therapeutic Target in Renal Cancer," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    • Handle: RePEc:plo:pone00:0076746
    DOI: 10.1371/journal.pone.0076746
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