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Smoking, BCG and Employment and the Risk of Tuberculosis Infection in HIV-Infected Persons in South Africa

Author

Listed:
  • Tolu Oni
  • Hannah P Gideon
  • Nonzwakazi Bangani
  • Relebohile Tsekela
  • Ronnett Seldon
  • Kathryn Wood
  • Katalin A Wilkinson
  • Rene T Goliath
  • Tom H M Ottenhoff
  • Robert J Wilkinson

Abstract

Background: The increased susceptibility to latent tuberculosis infection (LTBI) of HIV-1-infected persons represents a challenge in TB epidemic control. However few studies have evaluated LTBI predictors in a generalized HIV/TB epidemic setting. Methods: The study recruited 335 HIV-infected participants from Khayelitsha, Cape Town between February 2008 and November 2010. Tuberculin skin tests and interferon-gamma release assays were performed on all participants and active TB excluded using a symptom screen, TB microscopy and culture. Results: LTBI prevalence was 52.7% and 61.2% (TST and IGRA respectively). Being a recent TB contact (OR 2.07; 95% C.I. 1.15–3.69) was associated with TST positivity. Participants with a CD4>200 had a two-fold higher risk of IGRA positivity compared to those with CD4 counts

Suggested Citation

  • Tolu Oni & Hannah P Gideon & Nonzwakazi Bangani & Relebohile Tsekela & Ronnett Seldon & Kathryn Wood & Katalin A Wilkinson & Rene T Goliath & Tom H M Ottenhoff & Robert J Wilkinson, 2012. "Smoking, BCG and Employment and the Risk of Tuberculosis Infection in HIV-Infected Persons in South Africa," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-5, October.
    • Handle: RePEc:plo:pone00:0047072
    DOI: 10.1371/journal.pone.0047072
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    References listed on IDEAS

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    1. Rajnish Joshi & Arthur L Reingold & Dick Menzies & Madhukar Pai, 2006. "Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review," PLOS Medicine, Public Library of Science, vol. 3(12), pages 1-16, December.
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    1. Chrystal Bianca Udall & Christa Searle, 2023. "Modelling the Spread of Tuberculosis in South African Informal Settlements," SN Operations Research Forum, Springer, vol. 4(1), pages 1-17, March.

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