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Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese

Author

Listed:
  • Toshihiko Ohshige
  • Minoru Iwata
  • Shintaro Omori
  • Yasushi Tanaka
  • Hiroshi Hirose
  • Kohei Kaku
  • Hiroshi Maegawa
  • Hirotaka Watada
  • Atsunori Kashiwagi
  • Ryuzo Kawamori
  • Kazuyuki Tobe
  • Takashi Kadowaki
  • Yusuke Nakamura
  • Shiro Maeda

Abstract

Background: Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new European GWAS-derived susceptibility loci with type 2 diabetes in the Japanese population, we conducted a replication study using 3 independent Japanese case-control studies. Methodology/Principal Findings: We examined the association of single nucleotide polymorphisms (SNPs) within 13 loci (MTNR1B, GCK, IRS1, PROX1, BCL11A, ZBED3, KLF14, TP53INP1, KCNQ1, CENTD2, HMGA2, ZFAND6 and PRC1) with type 2 diabetes using 4,964 participants (2,839 cases and 2,125 controls) from 3 independent Japanese samples. The association of each SNP with type 2 diabetes was analyzed by logistic regression analysis. Further, we performed combined meta-analyses for the 3 studies and previously performed Japanese GWAS data (4,470 cases vs. 3,071 controls). The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05–1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P

Suggested Citation

  • Toshihiko Ohshige & Minoru Iwata & Shintaro Omori & Yasushi Tanaka & Hiroshi Hirose & Kohei Kaku & Hiroshi Maegawa & Hirotaka Watada & Atsunori Kashiwagi & Ryuzo Kawamori & Kazuyuki Tobe & Takashi Kad, 2011. "Association of New Loci Identified in European Genome-Wide Association Studies with Susceptibility to Type 2 Diabetes in the Japanese," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-5, October.
    • Handle: RePEc:plo:pone00:0026911
    DOI: 10.1371/journal.pone.0026911
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