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Can Animal Models of Disease Reliably Inform Human Studies?

Author

Listed:
  • H Bart van der Worp
  • David W Howells
  • Emily S Sena
  • Michelle J Porritt
  • Sarah Rewell
  • Victoria O'Collins
  • Malcolm R Macleod

Abstract

H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.

Suggested Citation

  • H Bart van der Worp & David W Howells & Emily S Sena & Michelle J Porritt & Sarah Rewell & Victoria O'Collins & Malcolm R Macleod, 2010. "Can Animal Models of Disease Reliably Inform Human Studies?," PLOS Medicine, Public Library of Science, vol. 7(3), pages 1-8, March.
    • Handle: RePEc:plo:pmed00:1000245
    DOI: 10.1371/journal.pmed.1000245
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    Cited by:

    1. Lauralyn A McIntyre & David Moher & Dean A Fergusson & Katrina J Sullivan & Shirley H J Mei & Manoj Lalu & John Marshall & Malcolm Mcleod & Gilly Griffin & Jeremy Grimshaw & Alexis Turgeon & Marc T Av, 2016. "Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-16, January.
    2. Susanne Wieschowski & Diego S Silva & Daniel Strech, 2016. "Animal Study Registries: Results from a Stakeholder Analysis on Potential Strengths, Weaknesses, Facilitators, and Barriers," PLOS Biology, Public Library of Science, vol. 14(11), pages 1-12, November.
    3. Philippa M Bennett & Sarah K Stewart & Janine Dretzke & Danai Bem & Jowan G Penn-Barwell, 2018. "Preclinical therapies to prevent or treat fracture non-union: A systematic review," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-22, August.
    4. Robyn M. Lucas & Rachael M. Rodney Harris, 2018. "On the Nature of Evidence and ‘Proving’ Causality: Smoking and Lung Cancer vs. Sun Exposure, Vitamin D and Multiple Sclerosis," IJERPH, MDPI, vol. 15(8), pages 1-13, August.
    5. Robin van Eenige & Peternella S Verhave & Peter J Koemans & Ivo A C W Tiebosch & Patrick C N Rensen & Sander Kooijman, 2020. "RandoMice, a novel, user-friendly randomization tool in animal research," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-8, August.
    6. Julie E. Goodman & Catherine Petito Boyce & Sonja N. Sax & Leslie A. Beyer & Robyn L. Prueitt, 2015. "Rethinking Meta‐Analysis: Applications for Air Pollution Data and Beyond," Risk Analysis, John Wiley & Sons, vol. 35(6), pages 1017-1039, June.
    7. Konstantinos K Tsilidis & Orestis A Panagiotou & Emily S Sena & Eleni Aretouli & Evangelos Evangelou & David W Howells & Rustam Al-Shahi Salman & Malcolm R Macleod & John P A Ioannidis, 2013. "Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases," PLOS Biology, Public Library of Science, vol. 11(7), pages 1-10, July.
    8. Adam R Ferguson & Karen-Amanda Irvine & John C Gensel & Jessica L Nielson & Amity Lin & Johnathan Ly & Mark R Segal & Rajiv R Ratan & Jacqueline C Bresnahan & Michael S Beattie, 2013. "Derivation of Multivariate Syndromic Outcome Metrics for Consistent Testing across Multiple Models of Cervical Spinal Cord Injury in Rats," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-13, March.
    9. Nathalie Percie du Sert & Viki Hurst & Amrita Ahluwalia & Sabina Alam & Marc T Avey & Monya Baker & William J Browne & Alejandra Clark & Innes C Cuthill & Ulrich Dirnagl & Michael Emerson & Paul Garne, 2020. "The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research," PLOS Biology, Public Library of Science, vol. 18(7), pages 1-12, July.
    10. Constance Holman & Sophie K Piper & Ulrike Grittner & Andreas Antonios Diamantaras & Jonathan Kimmelman & Bob Siegerink & Ulrich Dirnagl, 2016. "Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke," PLOS Biology, Public Library of Science, vol. 14(1), pages 1-12, January.
    11. Bossert, Leonie & Hagendorff, Thilo, 2021. "Animals and AI. The role of animals in AI research and application – An overview and ethical evaluation," Technology in Society, Elsevier, vol. 67(C).
    12. Carol Kilkenny & William J Browne & Innes C Cuthill & Michael Emerson & Douglas G Altman, 2010. "Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research," PLOS Biology, Public Library of Science, vol. 8(6), pages 1-5, June.
    13. David Krauth & Andrew Anglemyer & Rose Philipps & Lisa Bero, 2014. "Nonindustry-Sponsored Preclinical Studies on Statins Yield Greater Efficacy Estimates Than Industry-Sponsored Studies: A Meta-Analysis," PLOS Biology, Public Library of Science, vol. 12(1), pages 1-10, January.
    14. Kimberley E Wever & Carlijn R Hooijmans & Niels P Riksen & Thomas B Sterenborg & Emily S Sena & Merel Ritskes-Hoitinga & Michiel C Warlé, 2015. "Determinants of the Efficacy of Cardiac Ischemic Preconditioning: A Systematic Review and Meta-Analysis of Animal Studies," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-17, November.

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