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Signatures of neutral evolution in exponentially growing tumors: A theoretical perspective

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  • Hwai-Ray Tung
  • Rick Durrett

Abstract

Recent work of Sottoriva, Graham, and collaborators have led to the controversial claim that exponentially growing tumors have a site frequency spectrum that follows the 1/f law consistent with neutral evolution. This conclusion has been criticized based on data quality issues, statistical considerations, and simulation results. Here, we use rigorous mathematical arguments to investigate the site frequency spectrum in the two-type model of clonal evolution. If the fitnesses of the two types are λ0

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  • Hwai-Ray Tung & Rick Durrett, 2021. "Signatures of neutral evolution in exponentially growing tumors: A theoretical perspective," PLOS Computational Biology, Public Library of Science, vol. 17(2), pages 1-12, February.
    • Handle: RePEc:plo:pcbi00:1008701
    DOI: 10.1371/journal.pcbi.1008701
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    References listed on IDEAS

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    1. Durrett, Rick & Foo, Jasmine & Leder, Kevin & Mayberry, John & Michor, Franziska, 2010. "Evolutionary dynamics of tumor progression with random fitness values," Theoretical Population Biology, Elsevier, vol. 78(1), pages 54-66.
    2. Durrett, Richard & Moseley, Stephen, 2010. "Evolution of resistance and progression to disease during clonal expansion of cancer," Theoretical Population Biology, Elsevier, vol. 77(1), pages 42-48.
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