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Analysis validation has been neglected in the Age of Reproducibility

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  • Kathleen E Lotterhos
  • Jason H Moore
  • Ann E Stapleton

Abstract

Increasingly complex statistical models are being used for the analysis of biological data. Recent commentary has focused on the ability to compute the same outcome for a given dataset (reproducibility). We argue that a reproducible statistical analysis is not necessarily valid because of unique patterns of nonindependence in every biological dataset. We advocate that analyses should be evaluated with known-truth simulations that capture biological reality, a process we call “analysis validation.” We review the process of validation and suggest criteria that a validation project should meet. We find that different fields of science have historically failed to meet all criteria, and we suggest ways to implement meaningful validation in training and practice.Just as we do controls for experiments we should all do controls for data analysis – this is easy to say but requires dedication to implement. This Essay explains the need for analysis validation and provides specific suggestions for how to get started.

Suggested Citation

  • Kathleen E Lotterhos & Jason H Moore & Ann E Stapleton, 2018. "Analysis validation has been neglected in the Age of Reproducibility," PLOS Biology, Public Library of Science, vol. 16(12), pages 1-15, December.
    • Handle: RePEc:plo:pbio00:3000070
    DOI: 10.1371/journal.pbio.3000070
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    References listed on IDEAS

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    1. Philip B. Stark, 2018. "Before reproducibility must come preproducibility," Nature, Nature, vol. 557(7707), pages 613-613, May.
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