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Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins

Author

Listed:
  • Tommy Tsan-Yuk Lam

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Na Jia

    (Beijing Institute of Microbiology and Epidemiology)

  • Ya-Wei Zhang

    (Beijing Institute of Microbiology and Epidemiology)

  • Marcus Ho-Hin Shum

    (The University of Hong Kong)

  • Jia-Fu Jiang

    (Beijing Institute of Microbiology and Epidemiology)

  • Hua-Chen Zhu

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Yi-Gang Tong

    (Beijing University of Chemical Technology)

  • Yong-Xia Shi

    (Guangzhou Customs Technology Center)

  • Xue-Bing Ni

    (The University of Hong Kong)

  • Yun-Shi Liao

    (The University of Hong Kong)

  • Wen-Juan Li

    (Beijing University of Chemical Technology)

  • Bao-Gui Jiang

    (Beijing Institute of Microbiology and Epidemiology)

  • Wei Wei

    (Guangxi Medical University)

  • Ting-Ting Yuan

    (Beijing Institute of Microbiology and Epidemiology)

  • Kui Zheng

    (Guangzhou Customs Technology Center)

  • Xiao-Ming Cui

    (Beijing Institute of Microbiology and Epidemiology)

  • Jie Li

    (Beijing Institute of Microbiology and Epidemiology)

  • Guang-Qian Pei

    (Beijing Institute of Microbiology and Epidemiology)

  • Xin Qiang

    (Beijing Institute of Microbiology and Epidemiology)

  • William Yiu-Man Cheung

    (The University of Hong Kong)

  • Lian-Feng Li

    (Guangxi Medical University)

  • Fang-Fang Sun

    (Guangzhou Customs Technology Center)

  • Si Qin

    (Beijing Institute of Microbiology and Epidemiology)

  • Ji-Cheng Huang

    (Guangzhou Customs Technology Center)

  • Gabriel M. Leung

    (The University of Hong Kong)

  • Edward C. Holmes

    (The University of Sydney)

  • Yan-Ling Hu

    (Guangxi Medical University
    Guangxi Medical University)

  • Yi Guan

    (Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University
    The University of Hong Kong)

  • Wu-Chun Cao

    (Beijing Institute of Microbiology and Epidemiology)

Abstract

The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection2. Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manis javanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.

Suggested Citation

  • Tommy Tsan-Yuk Lam & Na Jia & Ya-Wei Zhang & Marcus Ho-Hin Shum & Jia-Fu Jiang & Hua-Chen Zhu & Yi-Gang Tong & Yong-Xia Shi & Xue-Bing Ni & Yun-Shi Liao & Wen-Juan Li & Bao-Gui Jiang & Wei Wei & Ting-, 2020. "Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins," Nature, Nature, vol. 583(7815), pages 282-285, July.
    • Handle: RePEc:nat:nature:v:583:y:2020:i:7815:d:10.1038_s41586-020-2169-0
    DOI: 10.1038/s41586-020-2169-0
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    2. Yinxian Zhang, 2023. "Impactful COVID-19 discoveries from China are neglected in the media," Scientometrics, Springer;Akadémiai Kiadó, vol. 128(8), pages 4523-4539, August.
    3. Yusuf Amuda Tajudeen & Iyiola Olatunji Oladunjoye & Ousman Bajinka & Habeebullah Jayeola Oladipo, 2022. "Zoonotic Spillover in an Era of Rapid Deforestation of Tropical Areas and Unprecedented Wildlife Trafficking: Into the Wild," Challenges, MDPI, vol. 13(2), pages 1-8, August.
    4. Ovidiu Tița & Maria Adelina Constantinescu & Mihaela Adriana Tița & Cecilia Georgescu, 2020. "Use of Yoghurt Enhanced with Volatile Plant Oils Encapsulated in Sodium Alginate to Increase the Human Body’s Immunity in the Present Fight Against Stress," IJERPH, MDPI, vol. 17(20), pages 1-17, October.
    5. Zepeng Xu & Xinrui Kang & Pu Han & Pei Du & Linjie Li & Anqi Zheng & Chuxia Deng & Jianxun Qi & Xin Zhao & Qihui Wang & Kefang Liu & George Fu Gao, 2022. "Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
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    7. Run-Ze Ye & Xiao-Yang Wang & Yu-Yu Li & Bao-Yu Wang & Ke Song & Yi-Fei Wang & Jing Liu & Bai-Hui Wang & Shan-Shan Wang & Qing Xu & Ze-Hui Li & Yi-Di Du & Jin-Yue Liu & Jia-Jing Zheng & Li-Feng Du & We, 2023. "Systematic review and integrated data analysis reveal diverse pangolin-associated microbes with infection potential," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    8. Nicola F. Müller & Kathryn E. Kistler & Trevor Bedford, 2022. "A Bayesian approach to infer recombination patterns in coronaviruses," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    9. Dinesh Kumar & Sejalben P. Antiya & Sandipkumar S. Patel & Ramesh Pandit & Madhvi Joshi & Abhinava K. Mishra & Chaitanya G. Joshi & Arunkumar C. Patel, 2022. "Surveillance and Molecular Characterization of SARS-CoV-2 Infection in Non-Human Hosts in Gujarat, India," IJERPH, MDPI, vol. 19(21), pages 1-11, November.
    10. Option Takunda Chiwaridzo & Reason Masengu, 2023. "The impact of social media branding and technology adoption on green tourism: the role of tourist behavior as a mediator in developing countries post-COVID-19—context of Zimbabwe," Future Business Journal, Springer, vol. 9(1), pages 1-14, December.
    11. Luo-Yuan Xia & Zhen-Fei Wang & Xiao-Ming Cui & Yuan-Guo Li & Run-Ze Ye & Dai-Yun Zhu & Fang-Xu Li & Jie Zhang & Wen-Hao Wang & Ming-Zhu Zhang & Wan-Ying Gao & Lian-Feng Li & Teng-Cheng Que & Tie-Cheng, 2024. "Isolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    12. Liang Leng & Zhichao Xu & Bixia Hong & Binbin Zhao & Ya Tian & Can Wang & Lulu Yang & Zhongmei Zou & Lingyu Li & Ke Liu & Wanjun Peng & Jiangning Liu & Zhoujie An & Yalin Wang & Baozhong Duan & Zhigan, 2024. "Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    13. Dongsheng Chen & Jian Sun & Jiacheng Zhu & Xiangning Ding & Tianming Lan & Xiran Wang & Weiying Wu & Zhihua Ou & Linnan Zhu & Peiwen Ding & Haoyu Wang & Lihua Luo & Rong Xiang & Xiaoling Wang & Jiayin, 2021. "Single cell atlas for 11 non-model mammals, reptiles and birds," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    14. Daniel N. Streblow & Alec J. Hirsch & Jeffrey J. Stanton & Anne D. Lewis & Lois Colgin & Ann J. Hessell & Craig N. Kreklywich & Jessica L. Smith & William F. Sutton & David Chauvin & Jennifer Woo & Be, 2023. "Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    15. Yusuf Amuda Tajudeen & Habeebullah Jayeola Oladipo & Rashidat Onyinoyi Yusuf & Iyiola Olatunji Oladunjoye & Aminat Olaitan Adebayo & Abdulhakeem Funsho Ahmed & Mona Said El-Sherbini, 2022. "The Need to Prioritize Prevention of Viral Spillover in the Anthropopandemicene: A Message to Global Health Researchers and Policymakers," Challenges, MDPI, vol. 13(2), pages 1-9, August.

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