IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v561y2018i7721d10.1038_s41586-018-0457-8.html
   My bibliography  Save this article

Facing up to the global challenges of ageing

Author

Listed:
  • Linda Partridge

    (Max Planck Institute for Biology of Ageing
    Evolution and Environment, UCL)

  • Joris Deelen

    (Max Planck Institute for Biology of Ageing
    Leiden University Medical Center)

  • P. Eline Slagboom

    (Max Planck Institute for Biology of Ageing
    Leiden University Medical Center)

Abstract

Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals and drugs can all improve late-life health in animals. Application to humans will require better biomarkers of disease risk and responses to interventions, closer alignment of work in animals and humans, and increased use of electronic health records, biobank resources and cohort studies.

Suggested Citation

  • Linda Partridge & Joris Deelen & P. Eline Slagboom, 2018. "Facing up to the global challenges of ageing," Nature, Nature, vol. 561(7721), pages 45-56, September.
    • Handle: RePEc:nat:nature:v:561:y:2018:i:7721:d:10.1038_s41586-018-0457-8
    DOI: 10.1038/s41586-018-0457-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-018-0457-8
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/s41586-018-0457-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sara Chimento-Díaz & Pablo Sánchez-García & Cristina Franco-Antonio & Esperanza Santano-Mogena & Isabel Espino-Tato & Sergio Cordovilla-Guardia, 2022. "Factors Associated with the Acceptance of New Technologies for Ageing in Place by People over 64 Years of Age," IJERPH, MDPI, vol. 19(5), pages 1-18, March.
    2. Theng Choon Ooi & Devinder Kaur Ajit Singh & Suzana Shahar & Razinah Sharif & Nurul Fatin Malek Rivan & Asheila Meramat & Nor Fadilah Rajab, 2022. "Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study," IJERPH, MDPI, vol. 19(12), pages 1-12, June.
    3. Hualong Chang & Mengxing Yao & Biao Chen & Yongle Qi & Jianli Zhang, 2022. "Effects of Blood Flow Restriction Combined with Low-Intensity Resistance Training on Lower-Limb Muscle Strength and Mass in Post-Middle-Aged Adults: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(23), pages 1-15, November.
    4. Aleksic, Slavisa & Atanasov, Michael & Agius, Jean Calleja & Camilleri, Kenneth & Čartolovni, Anto & Climent-Pérez, Pau & Colantonio, Sara & Cristina, Stefania & Despotovic, Vladimir & Ekenel, Hazim K, 2022. "State of the Art of Audio- and Video-Based Solutions for AAL," EconStor Research Reports 251553, ZBW - Leibniz Information Centre for Economics.
    5. Claudia Giacomozzi & Luigi Palmieri & Lidia Gargiulo & Cinzia Lo Noce & Laura Iannucci & Anna Di Lonardo & Serena Vannucchi & Graziano Onder & Furio Colivicchi & Simona Giampaoli & Chiara Donfrancesco, 2020. "The Perceived Health Status from Young Adults to Elderly: Results of the MEHM Questionnaire within the CUORE Project Survey 2008–2012," IJERPH, MDPI, vol. 17(17), pages 1-17, August.
    6. Olga Tena-Bernal & Marta Sánchez-Peña & Alba Gómez-Cabello & Carlos Salavera & Pablo Usán & Estela Calatayud, 2021. "Cognitive and Functional Differences in Aging with and without Intellectual Disabilities: Observational Study," Sustainability, MDPI, vol. 13(19), pages 1-14, September.
    7. Eleni-Marina Ashikali & Catherine Ludwig & Laura Mastromauro & Samuel Périvier & Aude Tholomier & Irina Ionita & Christophe Graf & Catherine Busnel, 2023. "Intrinsic Capacities, Functional Ability, Physiological Systems, and Caregiver Support: A Targeted Synthesis of Effective Interventions and International Recommendations for Older Adults," IJERPH, MDPI, vol. 20(5), pages 1-26, March.
    8. Adrián Hernández-Vicente & Jorge Marín-Puyalto & Esther Pueyo & Germán Vicente-Rodríguez & Nuria Garatachea, 2022. "Physical Activity in Centenarians beyond Cut-Point-Based Accelerometer Metrics," IJERPH, MDPI, vol. 19(18), pages 1-13, September.
    9. Nor Hana Ahmad Bahuri & Hussein Rizal & Mas Ayu Said & Phyo Kyaw Myint & Tin Tin Su, 2022. "Active Ageing Awareness and Quality of Life among Pre-Elder Malaysian Public Employees," IJERPH, MDPI, vol. 19(15), pages 1-19, July.
    10. Manzoor Ahmad Malik & S. P. Singh & Jyoti Jyoti & Falguni Pattanaik, 2022. "Work stress, health and wellbeing: evidence from the older adults labor market in India," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-8, December.
    11. Grant Stafford & Noemí Villén & Albert Roso-Llorach & Amelia Troncoso-Mariño & Mònica Monteagudo & Concepción Violán, 2021. "Combined Multimorbidity and Polypharmacy Patterns in the Elderly: A Cross-Sectional Study in Primary Health Care," IJERPH, MDPI, vol. 18(17), pages 1-22, September.
    12. Clesyane Alves Figueiredo & Daniella Pires Nunes & Suzimar de Fátima Benato Fusco & Maria Giovana Borges Saidel, 2023. "Perspectives of Brazilian Primary Care Nurses on Mental Health Care for Hypertensive Older Adults: A Qualitative Study," IJERPH, MDPI, vol. 20(12), pages 1-11, June.
    13. Young-Myoung Lim & Kang-Hyun Park & Ji-Hyuk Park, 2023. "Development of Lifestyle Evaluation Tools Based on the Values of the Elderly: A Delphi Study," SAGE Open, , vol. 13(3), pages 21582440231, September.
    14. Wenru Shang & Liping Guo & Yujia Liu & Yanfei Li & Qian Wei & Ke Guo & Minyan Yang & Lili Wei & Zheng Xu & Junqiang Niu & Xiuxia Li & Kehu Yang, 2023. "PROTOCOL: Non‐pharmacological interventions for older people with a diagnosis of depression: An evidence and gap map," Campbell Systematic Reviews, John Wiley & Sons, vol. 19(4), December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:561:y:2018:i:7721:d:10.1038_s41586-018-0457-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.