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Combined Multimorbidity and Polypharmacy Patterns in the Elderly: A Cross-Sectional Study in Primary Health Care

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  • Grant Stafford

    (Programa de Máster en Salud Pública, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Unitat Transversal de Recerca (UTR), Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain)

  • Noemí Villén

    (Àrea del Medicament i Servei de Farmàcia, Atenció Primària Barcelona Ciutat, Institut Català de la Salut (ICS), 08015 Barcelona, Spain
    Programa de Doctorat en Metodologia de la Recerca Biomèdica i Salut Pública, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona, Spain)

  • Albert Roso-Llorach

    (Unitat Transversal de Recerca (UTR), Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain
    Programa de Doctorat en Metodologia de la Recerca Biomèdica i Salut Pública, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona, Spain
    Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona, Spain)

  • Amelia Troncoso-Mariño

    (Àrea del Medicament i Servei de Farmàcia, Atenció Primària Barcelona Ciutat, Institut Català de la Salut (ICS), 08015 Barcelona, Spain
    Department of Clinical Sciences, University of Barcelona and IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Spain)

  • Mònica Monteagudo

    (Unitat Transversal de Recerca (UTR), Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain
    Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona, Spain)

  • Concepción Violán

    (Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), 08193 Barcelona, Spain
    Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitaria per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08303 Mataró, Spain)

Abstract

(1) Background: The acquisition of multiple chronic diseases, known as multimorbidity, is common in the elderly population, and it is often treated with the simultaneous consumption of several prescription drugs, known as polypharmacy. These two concepts are inherently related and cause an undue burden on the individual. The aim of this study was to identify combined multimorbidity and polypharmacy patterns for the elderly population in Catalonia. (2) Methods: A cross-sectional study using electronic health records from 2012 was conducted. A mapping process was performed linking chronic disease categories to the drug categories indicated for their treatment. A soft clustering technique was then carried out on the final mapped categories. (3) Results: 916,619 individuals were included, with 93.1% meeting the authors’ criteria for multimorbidity and 49.9% for polypharmacy. A seven-cluster solution was identified: one non-specific (Cluster 1) and six specific, corresponding to diabetes (Cluster 2), neurological and musculoskeletal, female dominant (Clusters 3 and 4) and cardiovascular, cerebrovascular and renal diseases (Clusters 5 and 6), and multi-system diseases (Cluster 7). (4) Conclusions: This study utilized a mapping process combined with a soft clustering technique to determine combined patterns of multimorbidity and polypharmacy in the elderly population, identifying overrepresentation in six of the seven clusters with chronic disease and chronic disease-drug categories. These results could be applied to clinical practice guidelines in order to better attend to patient needs. This study can serve as the foundation for future longitudinal regarding relationships between multimorbidity and polypharmacy.

Suggested Citation

  • Grant Stafford & Noemí Villén & Albert Roso-Llorach & Amelia Troncoso-Mariño & Mònica Monteagudo & Concepción Violán, 2021. "Combined Multimorbidity and Polypharmacy Patterns in the Elderly: A Cross-Sectional Study in Primary Health Care," IJERPH, MDPI, vol. 18(17), pages 1-22, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:17:p:9216-:d:626900
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    References listed on IDEAS

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    1. Linda Partridge & Joris Deelen & P. Eline Slagboom, 2018. "Facing up to the global challenges of ageing," Nature, Nature, vol. 561(7721), pages 45-56, September.
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    1. Maria Gabriella Melchiorre & Marco Socci & Sabrina Quattrini & Giovanni Lamura & Barbara D’Amen, 2022. "Frail Older People Ageing in Place in Italy: Use of Health Services and Relationship with General Practitioner," IJERPH, MDPI, vol. 19(15), pages 1-26, July.
    2. Yiming Chen & Lei Shi & Xiao Zheng & Juan Yang & Yaqing Xue & Shujuan Xiao & Benli Xue & Jiachi Zhang & Xinru Li & Huang Lin & Chao Ma & Chichen Zhang, 2022. "Patterns and Determinants of Multimorbidity in Older Adults: Study in Health-Ecological Perspective," IJERPH, MDPI, vol. 19(24), pages 1-15, December.

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