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TAM receptors regulate multiple features of microglial physiology

Author

Listed:
  • Lawrence Fourgeaud

    (Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies)

  • Paqui G. Través

    (Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
    Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM))

  • Yusuf Tufail

    (Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies)

  • Humberto Leal-Bailey

    (Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
    Joint Master in Neuroscience Program, University of Strasbourg)

  • Erin D. Lew

    (Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies)

  • Patrick G. Burrola

    (Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies)

  • Perri Callaway

    (Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies)

  • Anna Zagórska

    (Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies)

  • Carla V. Rothlin

    (Yale University School of Medicine)

  • Axel Nimmerjahn

    (Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies)

  • Greg Lemke

    (Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies
    Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies)

Abstract

Microglial phagocytosis is required for neurogenic niche maintenance and response to injury; the TAM kinases Mer and Axl are expressed by microglia in the adult CNS, and mediate the clearance of apoptotic cells from the niche.

Suggested Citation

  • Lawrence Fourgeaud & Paqui G. Través & Yusuf Tufail & Humberto Leal-Bailey & Erin D. Lew & Patrick G. Burrola & Perri Callaway & Anna Zagórska & Carla V. Rothlin & Axel Nimmerjahn & Greg Lemke, 2016. "TAM receptors regulate multiple features of microglial physiology," Nature, Nature, vol. 532(7598), pages 240-244, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7598:d:10.1038_nature17630
    DOI: 10.1038/nature17630
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    Cited by:

    1. Duy Pham & Xiao Tan & Brad Balderson & Jun Xu & Laura F. Grice & Sohye Yoon & Emily F. Willis & Minh Tran & Pui Yeng Lam & Arti Raghubar & Priyakshi Kalita-de Croft & Sunil Lakhani & Jana Vukovic & Ma, 2023. "Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    2. Lauren A Green & Julia C Nebiolo & Cody J Smith, 2019. "Microglia exit the CNS in spinal root avulsion," PLOS Biology, Public Library of Science, vol. 17(2), pages 1-30, February.
    3. Maciej K. Kocylowski & Hande Aypek & Wolfgang Bildl & Martin Helmstädter & Philipp Trachte & Bernhard Dumoulin & Sina Wittösch & Lukas Kühne & Ute Aukschun & Carolin Teetzen & Oliver Kretz & Botond Ga, 2022. "A slit-diaphragm-associated protein network for dynamic control of renal filtration," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Janik Engelmann & Jennifer Zarrer & Victoria Gensch & Kristoffer Riecken & Nikolaus Berenbrok & The Vinh Luu & Antonia Beitzen-Heineke & Maria Elena Vargas-Delgado & Klaus Pantel & Carsten Bokemeyer &, 2022. "Regulation of bone homeostasis by MERTK and TYRO3," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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