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In vivo genome editing using a high-efficiency TALEN system

Author

Listed:
  • Victoria M. Bedell

    (Mayo Clinic)

  • Ying Wang

    (Development and Cell Biology, Iowa State University)

  • Jarryd M. Campbell

    (Mayo Clinic)

  • Tanya L. Poshusta

    (Mayo Clinic)

  • Colby G. Starker

    (Cell Biology and Development, the Center for Genome Engineering, University of Minnesota)

  • Randall G. Krug II

    (Mayo Clinic)

  • Wenfang Tan

    (Cell Biology and Development, the Center for Genome Engineering, University of Minnesota)

  • Sumedha G. Penheiter

    (Mayo Clinic)

  • Alvin C. Ma

    (Mayo Clinic
    LKS Faculty of Medicine, the University of Hong Kong, Pok Fu Lam Road, Hong Kong)

  • Anskar Y. H. Leung

    (LKS Faculty of Medicine, the University of Hong Kong, Pok Fu Lam Road, Hong Kong)

  • Scott C. Fahrenkrug

    (Cell Biology and Development, the Center for Genome Engineering, University of Minnesota
    Recombinetics, Inc., 2575 University Ave. West, Suite 100, Saint Paul, Minnesota 55114, USA)

  • Daniel F. Carlson

    (Cell Biology and Development, the Center for Genome Engineering, University of Minnesota
    Recombinetics, Inc., 2575 University Ave. West, Suite 100, Saint Paul, Minnesota 55114, USA)

  • Daniel F. Voytas

    (Cell Biology and Development, the Center for Genome Engineering, University of Minnesota)

  • Karl J. Clark

    (Mayo Clinic)

  • Jeffrey J. Essner

    (Development and Cell Biology, Iowa State University)

  • Stephen C. Ekker

    (Mayo Clinic)

Abstract

Although zebrafish is an important animal model for basic vertebrate biology and human disease modelling, rapid targeted genome modification has not been possible in this species; here a technique based on improved artificial transcription activator-like effector nucleases (TALENs) allows precise sequence modifications at pre-determined genomic locations.

Suggested Citation

  • Victoria M. Bedell & Ying Wang & Jarryd M. Campbell & Tanya L. Poshusta & Colby G. Starker & Randall G. Krug II & Wenfang Tan & Sumedha G. Penheiter & Alvin C. Ma & Anskar Y. H. Leung & Scott C. Fahre, 2012. "In vivo genome editing using a high-efficiency TALEN system," Nature, Nature, vol. 491(7422), pages 114-118, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7422:d:10.1038_nature11537
    DOI: 10.1038/nature11537
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    Cited by:

    1. Valentina Cigliola & Adam Shoffner & Nutishia Lee & Jianhong Ou & Trevor J. Gonzalez & Jiaul Hoque & Clayton J. Becker & Yanchao Han & Grace Shen & Timothy D. Faw & Muhammad M. Abd-El-Barr & Shyni Var, 2023. "Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Ulaganathan, Kandasamy & Goud, Sravanthi & Reddy, Madhavi & Kayalvili, Ulaganathan, 2017. "Genome engineering for breaking barriers in lignocellulosic bioethanol production," Renewable and Sustainable Energy Reviews, Elsevier, vol. 74(C), pages 1080-1107.
    3. Shanmugam, Sabarathinam & Ngo, Huu-Hao & Wu, Yi-Rui, 2020. "Advanced CRISPR/Cas-based genome editing tools for microbial biofuels production: A review," Renewable Energy, Elsevier, vol. 149(C), pages 1107-1119.

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