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RNA-guided genetic silencing systems in bacteria and archaea

Author

Listed:
  • Blake Wiedenheft

    (Howard Hughes Medical Institute
    University of California
    Present address: Department of Immunology and Infectious Diseases, Montana State University, Bozeman, Montana, USA)

  • Samuel H. Sternberg

    (University of California)

  • Jennifer A. Doudna

    (Howard Hughes Medical Institute
    University of California
    University of California
    Lawrence Berkeley National Laboratory)

Abstract

Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNA interference (RNAi) pathways in eukaryotes, CRISPR-mediated immune systems rely on small RNAs for sequence-specific detection and silencing of foreign nucleic acids, including viruses and plasmids. However, the mechanism of RNA-based bacterial immunity is distinct from RNAi. Understanding how small RNAs are used to find and destroy foreign nucleic acids will provide new insights into the diverse mechanisms of RNA-controlled genetic silencing systems.

Suggested Citation

  • Blake Wiedenheft & Samuel H. Sternberg & Jennifer A. Doudna, 2012. "RNA-guided genetic silencing systems in bacteria and archaea," Nature, Nature, vol. 482(7385), pages 331-338, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7385:d:10.1038_nature10886
    DOI: 10.1038/nature10886
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    Citations

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    Cited by:

    1. Chongzhi Gong & Shengchan Huang & Rentao Song & Weiwei Qi, 2021. "Comparative Study between the CRISPR/Cpf1 (Cas12a) and CRISPR/Cas9 Systems for Multiplex Gene Editing in Maize," Agriculture, MDPI, vol. 11(5), pages 1-11, May.
    2. Vanessa M. Macias & Johanna R. Ohm & Jason L. Rasgon, 2017. "Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?," IJERPH, MDPI, vol. 14(9), pages 1-30, September.
    3. Ulaganathan, Kandasamy & Goud, Sravanthi & Reddy, Madhavi & Kayalvili, Ulaganathan, 2017. "Genome engineering for breaking barriers in lignocellulosic bioethanol production," Renewable and Sustainable Energy Reviews, Elsevier, vol. 74(C), pages 1080-1107.
    4. Rui Wang & Xian Shu & Huiwei Zhao & Qiong Xue & Chao Liu & Aici Wu & Feiyue Cheng & Lingyun Wang & Yihan Zhang & Jie Feng & Nannan Wu & Ming Li, 2023. "Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Eman A. Ageely & Ramadevi Chilamkurthy & Sunit Jana & Leonora Abdullahu & Daniel O’Reilly & Philip J. Jensik & Masad J. Damha & Keith T. Gagnon, 2021. "Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    6. Changshuang Jing & Min Wei & Peng Fang & Rentao Song & Weiwei Qi, 2021. "Pollen-Specific CRISPR/Cas9 System to Increase Heritable Gene Mutations in Maize," Agriculture, MDPI, vol. 11(8), pages 1-10, August.
    7. Rohan V Koodli & Benjamin Keep & Katherine R Coppess & Fernando Portela & Eterna participants & Rhiju Das, 2019. "EternaBrain: Automated RNA design through move sets and strategies from an Internet-scale RNA videogame," PLOS Computational Biology, Public Library of Science, vol. 15(6), pages 1-22, June.

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