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Evolution and metabolic significance of the urea cycle in photosynthetic diatoms

Author

Listed:
  • Andrew E. Allen

    (J. Craig Venter Institute
    CNRS UMR8197 INSERM U1024, Environmental and Evolutionary Genomics Section, Institute of Biology, Ecole Normale Supérieure, 46 rue d’Ulm)

  • Christopher L. Dupont

    (J. Craig Venter Institute)

  • Miroslav Oborník

    (Biology Centre ASCR, Institute of Parasitology and University of South Bohemia, Faculty of Science, Branišovská 31)

  • Aleš Horák

    (Biology Centre ASCR, Institute of Parasitology and University of South Bohemia, Faculty of Science, Branišovská 31)

  • Adriano Nunes-Nesi

    (Max-Planck-Insitut für Molekulare Pfanzenphysiologie
    Present addresses: Max Planck partner group Departamento de Biologia Vegetal, Universidade Federal de Viçosa, 36570-000 Viçosa, MG, Brasil (A.N-N.); Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China (H.H.).)

  • John P. McCrow

    (J. Craig Venter Institute)

  • Hong Zheng

    (J. Craig Venter Institute)

  • Daniel A. Johnson

    (J. Craig Venter Institute)

  • Hanhua Hu

    (CNRS UMR8197 INSERM U1024, Environmental and Evolutionary Genomics Section, Institute of Biology, Ecole Normale Supérieure, 46 rue d’Ulm
    Present addresses: Max Planck partner group Departamento de Biologia Vegetal, Universidade Federal de Viçosa, 36570-000 Viçosa, MG, Brasil (A.N-N.); Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China (H.H.).)

  • Alisdair R. Fernie

    (Max-Planck-Insitut für Molekulare Pfanzenphysiologie)

  • Chris Bowler

    (CNRS UMR8197 INSERM U1024, Environmental and Evolutionary Genomics Section, Institute of Biology, Ecole Normale Supérieure, 46 rue d’Ulm)

Abstract

Role reversal for diatoms' urea cycle Recent genome analysis has suggested that an ornithine-urea cycle similar to that found in metazoans is present in diatoms, unicellular algae important in marine ecosystems. This was a surprise because the urea cycle had long been thought to have arisen in metazoans as a crucial pathway for cellular removal of fixed nitrogen. Functional analyses of the diatom urea-cycle enzyme carbamoyl phosphate synthase now reveal a novel role for the urea cycle in intracellular recovery of inorganic carbon and nitrogen. This pathway may contribute to the metabolic response of diatoms to episodic nitrogen availability, and may have an important role in carbon fixation into nitrogenous compounds essential for diatom growth and for the contribution of diatoms to marine productivity.

Suggested Citation

  • Andrew E. Allen & Christopher L. Dupont & Miroslav Oborník & Aleš Horák & Adriano Nunes-Nesi & John P. McCrow & Hong Zheng & Daniel A. Johnson & Hanhua Hu & Alisdair R. Fernie & Chris Bowler, 2011. "Evolution and metabolic significance of the urea cycle in photosynthetic diatoms," Nature, Nature, vol. 473(7346), pages 203-207, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7346:d:10.1038_nature10074
    DOI: 10.1038/nature10074
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    1. Enamala, Manoj Kumar & Enamala, Swapnika & Chavali, Murthy & Donepudi, Jagadish & Yadavalli, Rajasri & Kolapalli, Bhulakshmi & Aradhyula, Tirumala Vasu & Velpuri, Jeevitha & Kuppam, Chandrasekhar, 2018. "Production of biofuels from microalgae - A review on cultivation, harvesting, lipid extraction, and numerous applications of microalgae," Renewable and Sustainable Energy Reviews, Elsevier, vol. 94(C), pages 49-68.
    2. Dugdale, Richard C. & Wilkerson, Frances P. & Parker, Alexander E., 2016. "The effect of clam grazing on phytoplankton spring blooms in the low-salinity zone of the San Francisco Estuary: A modelling approach," Ecological Modelling, Elsevier, vol. 340(C), pages 1-16.
    3. Zhang, Bing & Li, Wei & Guo, Yuan & Zhang, Zhiqiang & Shi, Wenxin & Cui, Fuyi & Lens, Piet N.L. & Tay, Joo Hwa, 2020. "Microalgal-bacterial consortia: From interspecies interactions to biotechnological applications," Renewable and Sustainable Energy Reviews, Elsevier, vol. 118(C).

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