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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Author

Listed:
  • Sheau-Fang Ng

    (School of Medical Sciences, University of New South Wales, New South Wales)

  • Ruby C. Y. Lin

    (Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, University of New South Wales, New South Wales)

  • D. Ross Laybutt

    (Garvan Institute of Medical Research)

  • Romain Barres

    (School of Medical Sciences, University of New South Wales)

  • Julie A. Owens

    (School of Paediatrics and Reproductive Health, University of Adelaide)

  • Margaret J. Morris

    (School of Medical Sciences, University of New South Wales, New South Wales)

Abstract

Paternal diet linked to glucose intolerance in daughters Childhood obesity and diabetes are closely related to these conditions in either parent, but how the father contributes is unclear. A study in rats shows that normal females mated with obese, glucose-intolerant fathers on a high-fat diet produce female offspring who develop glucose intolerance due to impaired insulin secretion and pancreatic function. This is the first report in any species that a father's diet can initiate progression to diabetes in his offspring. The work highlights a novel role for environmentally induced paternal factors in influencing metabolic disease in offspring and in the growing epidemics of obesity and diabetes.

Suggested Citation

  • Sheau-Fang Ng & Ruby C. Y. Lin & D. Ross Laybutt & Romain Barres & Julie A. Owens & Margaret J. Morris, 2010. "Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring," Nature, Nature, vol. 467(7318), pages 963-966, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7318:d:10.1038_nature09491
    DOI: 10.1038/nature09491
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    Cited by:

    1. Ramya Potabattula & Marcus Dittrich & Martin Schorsch & Thomas Hahn & Thomas Haaf & Nady El Hajj, 2019. "Male obesity effects on sperm and next-generation cord blood DNA methylation," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-13, June.
    2. Angela Jane Crean & Alistair McNair Senior & Therese Freire & Thomas Daniel Clark & Flora Mackay & Gracie Austin & Tamara Jayne Pulpitel & Marcelo Aguiar Nobrega & Romain Barrès & Stephen James Simpso, 2024. "Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Carlos Olmeda-Gómez & Carlos Romá-Mateo & Maria-Antonia Ovalle-Perandones, 2019. "Overview of trends in global epigenetic research (2009–2017)," Scientometrics, Springer;Akadémiai Kiadó, vol. 119(3), pages 1545-1574, June.
    4. van den Berg, Gerard J. & Pinger, Pia R., 2016. "Transgenerational effects of childhood conditions on third generation health and education outcomes," Economics & Human Biology, Elsevier, vol. 23(C), pages 103-120.
    5. Elias L. Khalil, 2012. "Are Instincts Hardened Routines? A Radical Proposal," Monash Economics Working Papers 25-12, Monash University, Department of Economics.
    6. Marianne Lønnebotn & Natalia El-Merhie & John W. Holloway & William Horsnell & Susanne Krauss-Etschmann & Francisco Gómez Real & Cecilie Svanes, 2018. "Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models," Challenges, MDPI, vol. 9(2), pages 1-16, December.
    7. Nicolas Todd & Sophie Le Fur & Pierre Bougnères & Alain-Jacques Valleron, 2017. "Impact of social inequalities at birth on the longevity of children born 1914–1916: A cohort study," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.
    8. Gerd Toril Mørkve Knudsen & Shyamali Dharmage & Christer Janson & Michael J Abramson & Bryndís Benediktsdóttir & Andrei Malinovschi & Svein Magne Skulstad & Randi Jacobsen Bertelsen & Francisco Gomez , 2020. "Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-20, July.

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