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Biological, clinical and population relevance of 95 loci for blood lipids

Author

Listed:
  • Tanya M. Teslovich

    (Center for Statistical Genetics, University of Michigan)

  • Kiran Musunuru

    (Center for Human Genetic Research, Massachusetts General Hospital
    Cardiovascular Research Center, Massachusetts General Hospital
    Broad Institute
    Johns Hopkins University School of Medicine)

  • Albert V. Smith

    (Icelandic Heart Association, Heart Preventive Clinic and Research Institute
    University of Iceland)

  • Andrew C. Edmondson

    (Cardiovascular Institute, University of Pennsylvania School of Medicine
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine)

  • Ioannis M. Stylianou

    (Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine)

  • Masahiro Koseki

    (Columbia University)

  • James P. Pirruccello

    (Center for Human Genetic Research, Massachusetts General Hospital
    Broad Institute
    Johns Hopkins University School of Medicine)

  • Samuli Ripatti

    (Institute for Molecular Medicine Finland FIMM, University of Helsinki
    National Institute for Health and Welfare, P.O. Box 104, FI-00251 Helsinki, Finland.)

  • Daniel I. Chasman

    (Brigham and Women’s Hospital)

  • Cristen J. Willer

    (Center for Statistical Genetics, University of Michigan)

  • Christopher T. Johansen

    (Robarts Research Institute, University of Western Ontario)

  • Sigrid W. Fouchier

    (Academic Medical Centre at the University of Amsterdam)

  • Aaron Isaacs

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.)

  • Gina M. Peloso

    (Boston University School of Public Health
    National Heart, Lung and Blood Institute’s Framingham Heart Study)

  • Maja Barbalic

    (Human Genetics Center, University of Texas Health Science Center at Houston)

  • Sally L. Ricketts

    (Strangeways Research Laboratory, University of Cambridge)

  • Joshua C. Bis

    (University of Washington)

  • Yurii S. Aulchenko

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.)

  • Gudmar Thorleifsson

    (deCODE Genetics)

  • Mary F. Feitosa

    (Washington University School of Medicine)

  • John Chambers

    (Imperial College London)

  • Marju Orho-Melander

    (Lund University)

  • Olle Melander

    (Lund University)

  • Toby Johnson

    (Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London)

  • Xiaohui Li

    (Medical Genetics Institute, Cedars-Sinai Medical Center)

  • Xiuqing Guo

    (Medical Genetics Institute, Cedars-Sinai Medical Center)

  • Mingyao Li

    (Cardiovascular Institute, University of Pennsylvania School of Medicine
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine)

  • Yoon Shin Cho

    (Center for Genome Science, National Institute of Health)

  • Min Jin Go

    (Center for Genome Science, National Institute of Health)

  • Young Jin Kim

    (Center for Genome Science, National Institute of Health)

  • Jong-Young Lee

    (Center for Genome Science, National Institute of Health)

  • Taesung Park

    (Interdisciplinary Program in Bioinformatics, College of Natural Sciences, Seoul National University
    College of Natural Sciences, Seoul National University)

  • Kyunga Kim

    (Sookmyung Women’s University)

  • Xueling Sim

    (Centre for Molecular Epidemiology, National University of Singapore)

  • Rick Twee-Hee Ong

    (Genome Institute of Singapore)

  • Damien C. Croteau-Chonka

    (University of North Carolina)

  • Leslie A. Lange

    (University of North Carolina)

  • Joshua D. Smith

    (University of Washington)

  • Kijoung Song

    (GlaxoSmithKline R&D)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Xin Yuan

    (GlaxoSmithKline R&D)

  • Jian’an Luan

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Claudia Lamina

    (Molecular and Clinical Pharmacology, Innsbruck Medical University, Schoepfstrasse 41, A-6020 Innsbruck, Austria.)

  • Andreas Ziegler

    (Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck)

  • Weihua Zhang

    (Imperial College London)

  • Robert Y. L. Zee

    (Brigham and Women’s Hospital)

  • Alan F. Wright

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine)

  • Jacqueline C. M. Witteman

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) and Center of Medical Systems Biology (CMSB))

  • James F. Wilson

    (Centre for Population Health Sciences, University of Edinburgh)

  • Gonneke Willemsen

    (VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.)

  • H.-Erich Wichmann

    (Institute of Epidemiology, Helmholtz Zentrum Munchen – German Research Center for Environmental Health)

  • John B. Whitfield

    (Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital)

  • Dawn M. Waterworth

    (GlaxoSmithKline R&D)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Gérard Waeber

    (Centre Hospitalier Universitaire Vaudois)

  • Peter Vollenweider

    (Centre Hospitalier Universitaire Vaudois)

  • Benjamin F. Voight

    (Center for Human Genetic Research, Massachusetts General Hospital
    Broad Institute)

  • Veronique Vitart

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine)

  • Andre G. Uitterlinden

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) and Center of Medical Systems Biology (CMSB)
    Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.)

  • Manuela Uda

    (Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy.)

  • Jaakko Tuomilehto

    (National Institute for Health and Welfare)

  • John R. Thompson

    (University of Leicester)

  • Toshiko Tanaka

    (Clinical Research Branch, National Institute on Aging, National Institutes of Health
    Medstar Research Institute)

  • Ida Surakka

    (Institute for Molecular Medicine Finland FIMM, University of Helsinki
    National Institute for Health and Welfare, P.O. Box 104, FI-00251 Helsinki, Finland.)

  • Heather M. Stringham

    (Center for Statistical Genetics, University of Michigan)

  • Tim D. Spector

    (King’s College London)

  • Nicole Soranzo

    (King’s College London
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.)

  • Johannes H. Smit

    (EMGO Institute, Neuroscience Campus Amsterdam, VU University Medical Center)

  • Juha Sinisalo

    (Helsinki University Central Hospital (HUCH))

  • Kaisa Silander

    (Institute for Molecular Medicine Finland FIMM, University of Helsinki
    National Institute for Health and Welfare, P.O. Box 104, FI-00251 Helsinki, Finland.)

  • Eric J. G. Sijbrands

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
    Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.)

  • Angelo Scuteri

    (Unita Operativa Geriatria, Istituto Nazionale Ricovero e Cura Anziani (INRCA), Istituto Ricovero e Cura a Carattere Scientifico (IRCCS), Via Cassia 1167, 00189 Rome, Italy.)

  • James Scott

    (Hammersmith Hospital, National Heart and Lung Institute, Imperial College London)

  • David Schlessinger

    (Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA.)

  • Serena Sanna

    (Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy.)

  • Veikko Salomaa

    (National Institute for Health and Welfare)

  • Juha Saharinen

    (Institute for Molecular Medicine Finland FIMM, University of Helsinki)

  • Chiara Sabatti

    (Stanford University)

  • Aimo Ruokonen

    (University of Oulu)

  • Igor Rudan

    (Centre for Population Health Sciences, University of Edinburgh)

  • Lynda M. Rose

    (Brigham and Women’s Hospital)

  • Robert Roberts

    (The John & Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa)

  • Mark Rieder

    (University of Washington)

  • Bruce M. Psaty

    (Epidemiology, and Health Services, University of Washington, Group Health Research Institute, Group Health Cooperative)

  • Peter P. Pramstaller

    (Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy – affiliated institute of the University of Lübeck)

  • Irene Pichler

    (Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy – affiliated institute of the University of Lübeck)

  • Markus Perola

    (Institute for Molecular Medicine Finland FIMM, University of Helsinki
    National Institute for Health and Welfare, P.O. Box 104, FI-00251 Helsinki, Finland.)

  • Brenda W. J. H. Penninx

    (EMGO Institute, Neuroscience Campus Amsterdam, VU University Medical Center)

  • Nancy L. Pedersen

    (Karolinska Institutet)

  • Cristian Pattaro

    (Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy – affiliated institute of the University of Lübeck)

  • Alex N. Parker

    (Amgen, Thousand Oaks, California 91320, USA.)

  • Guillaume Pare

    (Genetic and Molecular Epidemiology Laboratory, McMaster University)

  • Ben A. Oostra

    (Erasmus University Medical Center)

  • Christopher J. O’Donnell

    (National Heart, Lung and Blood Institute’s Framingham Heart Study)

  • Markku S. Nieminen

    (Helsinki University Central Hospital (HUCH))

  • Deborah A. Nickerson

    (University of Washington)

  • Grant W. Montgomery

    (Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital)

  • Thomas Meitinger

    (Institut fur Humangenetik, Helmholtz Zentrum Munchen, Deutsches Forschungszentrum fur Umwelt und Gesundheit
    Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München)

  • Ruth McPherson

    (The John & Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
    Oxford Centre for Diabetes, Endocrinology and Medicine, University of Oxford, Churchill Hospital
    Oxford NIHR Biomedical Research Centre, Churchill Hospital)

  • Wendy McArdle

    (Avon Longitudinal Study of Parents and Children, University of Bristol)

  • David Masson

    (Columbia University)

  • Nicholas G. Martin

    (Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital)

  • Fabio Marroni

    (Institute of Applied Genomics, via Linussio 51, 33100 Udine, Italy.)

  • Massimo Mangino

    (King’s College London)

  • Patrik K. E. Magnusson

    (Karolinska Institutet)

  • Gavin Lucas

    (Cardiovascular Epidemiology and Genetics, Institut Municipal d’Investigacio Medica)

  • Robert Luben

    (Strangeways Research Laboratory, University of Cambridge)

  • Ruth J. F. Loos

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Marja-Liisa Lokki

    (Transplantation Laboratory, Haartman Institute, University of Helsinki)

  • Guillaume Lettre

    (Montreal Heart Institute (Research Center), Université de Montréal)

  • Claudia Langenberg

    (MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital)

  • Lenore J. Launer

    (Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health)

  • Edward G. Lakatta

    (Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA.)

  • Reijo Laaksonen

    (Science Center, Tampere University Hospital)

  • Kirsten O. Kyvik

    (Institute of Regional Health Research and the Danish Twin Registry, Institute of Public Health, University of Southern Denmark, JBWinsløws Vej 9B, DK-5000, Odense, Denmark.)

  • Florian Kronenberg

    (Molecular and Clinical Pharmacology, Innsbruck Medical University, Schoepfstrasse 41, A-6020 Innsbruck, Austria.)

  • Inke R. König

    (Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck)

  • Kay-Tee Khaw

    (Strangeways Research Laboratory, University of Cambridge)

  • Jaakko Kaprio

    (Institute for Molecular Medicine Finland FIMM, University of Helsinki
    National Institute for Health and Welfare, P.O. Box 104, FI-00251 Helsinki, Finland.
    Faculty of Medicine, University of Helsinki)

  • Lee M. Kaplan

    (Massachusetts General Hospital Weight Center)

  • Åsa Johansson

    (Rudbeck Laboratory, University of Uppsala)

  • Marjo-Riitta Jarvelin

    (Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK.
    University of Oulu)

  • A. Cecile J. W. Janssens

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.)

  • Erik Ingelsson

    (Karolinska Institutet)

  • Wilmar Igl

    (Rudbeck Laboratory, University of Uppsala)

  • G. Kees Hovingh

    (Academic Medical Centre at the University of Amsterdam)

  • Jouke-Jan Hottenga

    (VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.)

  • Albert Hofman

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) and Center of Medical Systems Biology (CMSB))

  • Andrew A. Hicks

    (Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Viale Druso 1, 39100 Bolzano, Italy – affiliated institute of the University of Lübeck)

  • Christian Hengstenberg

    (Klinik und Poliklinik für Innere Medizin II, Universität Regensburg)

  • Iris M. Heid

    (Institute of Epidemiology, Helmholtz Zentrum Munchen – German Research Center for Environmental Health
    Department of Epidemiology and Preventive Medicine Regensburg University Medical Center Franz-Josef-Strauss-Allee 11)

  • Caroline Hayward

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine)

  • Aki S. Havulinna

    (National Institute for Health and Welfare
    Aalto University School of Science and Technology)

  • Nicholas D. Hastie

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine)

  • Tamara B. Harris

    (Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health)

  • Talin Haritunians

    (Medical Genetics Institute, Cedars-Sinai Medical Center)

  • Alistair S. Hall

    (LIGHT Research Institute, Faculty of Medicine and Health, University of Leeds)

  • Ulf Gyllensten

    (Rudbeck Laboratory, University of Uppsala)

  • Candace Guiducci

    (Broad Institute)

  • Leif C. Groop

    (Lund University
    Helsinki University Hospital)

  • Elena Gonzalez

    (Broad Institute)

  • Christian Gieger

    (Institute of Epidemiology, Helmholtz Zentrum Munchen – German Research Center for Environmental Health)

  • Nelson B. Freimer

    (Center for Neurobehavioral Genetics, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California)

  • Luigi Ferrucci

    (Clinical Research Branch, National Institute on Aging, National Institutes of Health)

  • Jeanette Erdmann

    (Medizinische Klinik II, Universität zu Lübeck)

  • Paul Elliott

    (Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK.
    MRC-HPA Centre for Environment and Health, Imperial College London)

  • Kenechi G. Ejebe

    (Broad Institute)

  • Angela Döring

    (Institute of Epidemiology, Helmholtz Zentrum Munchen – German Research Center for Environmental Health)

  • Anna F. Dominiczak

    (BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.)

  • Serkalem Demissie

    (Boston University School of Public Health
    National Heart, Lung and Blood Institute’s Framingham Heart Study)

  • Panagiotis Deloukas

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.)

  • Eco J. C. de Geus

    (VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.)

  • Ulf de Faire

    (Institute of Environmental Medicine, Karolinska Institutet)

  • Gabriel Crawford

    (Broad Institute)

  • Francis S. Collins

    (National Human Genome Research Institute, National Institutes of Health)

  • Yii-der I. Chen

    (Medical Genetics Institute, Cedars-Sinai Medical Center)

  • Mark J. Caulfield

    (Clinical Pharmacology and Barts and the London Genome Centre, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London)

  • Harry Campbell

    (Centre for Population Health Sciences, University of Edinburgh)

  • Noel P. Burtt

    (Broad Institute)

  • Lori L. Bonnycastle

    (National Human Genome Research Institute, National Institutes of Health)

  • Dorret I. Boomsma

    (VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.)

  • S. Matthijs Boekholdt

    (Academic Medical Centre)

  • Richard N. Bergman

    (University of Southern California)

  • Inês Barroso

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.)

  • Stefania Bandinelli

    (Geriatric Unit, Azienda Sanitaria Firenze (ASF))

  • Christie M. Ballantyne

    (Baylor College of Medicine)

  • Themistocles L. Assimes

    (Stanford University School of Medicine)

  • Thomas Quertermous

    (Stanford University School of Medicine)

  • David Altshuler

    (Center for Human Genetic Research, Massachusetts General Hospital
    Broad Institute)

  • Mark Seielstad

    (Genome Institute of Singapore)

  • Tien Y. Wong

    (Singapore Eye Research Institute, National University of Singapore)

  • E-Shyong Tai

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Alan B. Feranil

    (Office of Population Studies Foundation, University of San Carlos)

  • Christopher W. Kuzawa

    (Northwestern University)

  • Linda S. Adair

    (Carolina Population Center, University of North Carolina)

  • Herman A. Taylor Jr

    (University of Mississippi Medical Center)

  • Ingrid B. Borecki

    (Washington University School of Medicine)

  • Stacey B. Gabriel

    (Broad Institute)

  • James G. Wilson

    (University of Mississippi Medical Center)

  • Hilma Holm

    (deCODE Genetics)

  • Unnur Thorsteinsdottir

    (University of Iceland
    deCODE Genetics)

  • Vilmundur Gudnason

    (Icelandic Heart Association, Heart Preventive Clinic and Research Institute
    University of Iceland)

  • Ronald M. Krauss

    (Children’s Hospital Oakland Research Institute)

  • Karen L. Mohlke

    (University of North Carolina)

  • Jose M. Ordovas

    (Centro Nacional de Investigaciones Cardiovasculares
    Nutrition and Genomics Laboratory)

  • Patricia B. Munroe

    (Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.)

  • Jaspal S. Kooner

    (Hammersmith Hospital, National Heart and Lung Institute, Imperial College London)

  • Alan R. Tall

    (Columbia University)

  • Robert A. Hegele

    (Robarts Research Institute, University of Western Ontario)

  • John J.P. Kastelein

    (Academic Medical Centre at the University of Amsterdam)

  • Eric E. Schadt

    (Sage Bionetworks)

  • Jerome I. Rotter

    (Medical Genetics Institute, Cedars-Sinai Medical Center)

  • Eric Boerwinkle

    (Human Genetics Center, University of Texas Health Science Center at Houston)

  • David P. Strachan

    (St George’s University of London)

  • Vincent Mooser

    (GlaxoSmithKline R&D)

  • Kari Stefansson

    (University of Iceland
    deCODE Genetics)

  • Muredach P. Reilly

    (Cardiovascular Institute, University of Pennsylvania School of Medicine
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine)

  • Nilesh J Samani

    (University of Leicester, NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital)

  • Heribert Schunkert

    (Medizinische Klinik II, Universität zu Lübeck)

  • L. Adrienne Cupples

    (Boston University School of Public Health
    National Heart, Lung and Blood Institute’s Framingham Heart Study)

  • Manjinder S. Sandhu

    (Strangeways Research Laboratory, University of Cambridge
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.)

  • Paul M Ridker

    (Brigham and Women’s Hospital)

  • Daniel J. Rader

    (Cardiovascular Institute, University of Pennsylvania School of Medicine
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine)

  • Cornelia M. van Duijn

    (Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA) and Center of Medical Systems Biology (CMSB))

  • Leena Peltonen
  • Gonçalo R. Abecasis

    (Center for Statistical Genetics, University of Michigan)

  • Michael Boehnke

    (Center for Statistical Genetics, University of Michigan)

  • Sekar Kathiresan

    (Center for Human Genetic Research, Massachusetts General Hospital
    Cardiovascular Research Center, Massachusetts General Hospital
    Broad Institute)

Abstract

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P

Suggested Citation

  • Tanya M. Teslovich & Kiran Musunuru & Albert V. Smith & Andrew C. Edmondson & Ioannis M. Stylianou & Masahiro Koseki & James P. Pirruccello & Samuli Ripatti & Daniel I. Chasman & Cristen J. Willer & C, 2010. "Biological, clinical and population relevance of 95 loci for blood lipids," Nature, Nature, vol. 466(7307), pages 707-713, August.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7307:d:10.1038_nature09270
    DOI: 10.1038/nature09270
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    Cited by:

    1. Peter H. Dixon & Adam P. Levine & Inês Cebola & Melanie M. Y. Chan & Aliya S. Amin & Anshul Aich & Monika Mozere & Hannah Maude & Alice L. Mitchell & Jun Zhang & Jenny Chambers & Argyro Syngelaki & Je, 2022. "GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Mike Thompson & Mary Grace Gordon & Andrew Lu & Anchit Tandon & Eran Halperin & Alexander Gusev & Chun Jimmie Ye & Brunilda Balliu & Noah Zaitlen, 2022. "Multi-context genetic modeling of transcriptional regulation resolves novel disease loci," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Maria Mirabelli & Eusebio Chiefari & Patrizia Caroleo & Biagio Arcidiacono & Domenica Maria Corigliano & Stefania Giuliano & Francesco Saverio Brunetti & Sinan Tanyolaç & Daniela Patrizia Foti & Luigi, 2019. "Long-Term Effectiveness of Liraglutide for Weight Management and Glycemic Control in Type 2 Diabetes," IJERPH, MDPI, vol. 17(1), pages 1-11, December.
    4. Yang, Chiao-Yu & Lei, Lihua & Ho, Nhat & Fithian, William, 2022. "BONuS: Multiple Multivariate Testing with a Data-Adaptive Test Statistic," Research Papers 4031, Stanford University, Graduate School of Business.
    5. Linda Ottensmann & Rubina Tabassum & Sanni E. Ruotsalainen & Mathias J. Gerl & Christian Klose & Elisabeth Widén & Kai Simons & Samuli Ripatti & Matti Pirinen, 2023. "Genome-wide association analysis of plasma lipidome identifies 495 genetic associations," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Sonali Pechlivanis & Susanne Moebus & Nils Lehmann & Raimund Erbel & Amir A Mahabadi & Per Hoffmann & Karl-Heinz Jöckel & Markus M Nöthen & Hagen S Bachmann & on behalf of the Heinz Nixdorf Recall Stu, 2020. "Genetic risk scores for coronary artery disease and its traditional risk factors: Their role in the progression of coronary artery calcification—Results of the Heinz Nixdorf Recall study," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-18, May.
    7. Xinyuan Zhang & Anastasia M. Lucas & Yogasudha Veturi & Theodore G. Drivas & William P. Bone & Anurag Verma & Wendy K. Chung & David Crosslin & Joshua C. Denny & Scott Hebbring & Gail P. Jarvik & Ifti, 2022. "Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    8. Jiacheng Miao & Hanmin Guo & Gefei Song & Zijie Zhao & Lin Hou & Qiongshi Lu, 2023. "Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
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    10. Jordi Manuello & Joosung Min & Paul McCarthy & Fidel Alfaro-Almagro & Soojin Lee & Stephen Smith & Lloyd T. Elliott & Anderson M. Winkler & Gwenaëlle Douaud, 2024. "The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
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