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Long-Term Effectiveness of Liraglutide for Weight Management and Glycemic Control in Type 2 Diabetes

Author

Listed:
  • Maria Mirabelli

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
    These authors contribute equally to this work.)

  • Eusebio Chiefari

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
    These authors contribute equally to this work.)

  • Patrizia Caroleo

    (Complex Operative Structure Endocrinology-Diabetology, Hospital Pugliese-Ciaccio, 88100 Catanzaro, Italy)

  • Biagio Arcidiacono

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Domenica Maria Corigliano

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Stefania Giuliano

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Francesco Saverio Brunetti

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Sinan Tanyolaç

    (Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Biruni University, 34010 Istanbul, Turkey)

  • Daniela Patrizia Foti

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Luigi Puccio

    (Complex Operative Structure Endocrinology-Diabetology, Hospital Pugliese-Ciaccio, 88100 Catanzaro, Italy)

  • Antonio Brunetti

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

Abstract

Background : Liraglutide is the first glucagon-like peptide-1 receptor agonist (GLP-1 RA) based on the human GLP-1 sequence, with potential weight loss benefits, approved for the treatment of type 2 diabetes (T2D) mellitus. Herein, we aimed to assess the 5-year effectiveness of Liraglutide in the management of weight and glycometabolic control in a Southern Italian cohort of overweight/obese T2D patients, who were naïve to GLP-1 RAs. Patients and Methods : Forty overweight or obese patients treated with Liraglutide at doses up to 1.8 mg/day, in combination with one or more oral antidiabetic agents, were retrospectively assessed at baseline, during, and after 60 months of continuous therapy. Results : After 5 years of Liraglutide treatment, body weight decreased from 92.1 ± 20.5 kg to 87.3 ± 20.0 Kg ( p < 0.001), with a mean reduction of 5.0 ± 7.0 Kg and a body mass index (BMI) decrement of −2.0 ± 3.1 Kg/m 2 . On Spearman’s univariate analysis, change in body weight was correlated with female gender and baseline BMI. Hemoglobin A1c (HbA1c) decreased from 7.9 ± 0.9% at baseline to 7.0 ± 0.7% at the end of the study period ( p < 0.001), followed by a significant reduction in fasting plasma glucose. No significant differences emerged in other biochemical parameters, despite a trend toward improvement in lipid profile. Notwithstanding encouraging effects on several markers of cardiovascular disease (CVD), increments in the 5- and 10-year risk for the first atherosclerotic cardiovascular event were documented, as four incident cases of myocardial infarction. Conclusions : Prolonging treatment with Liraglutide can lead to durable benefits in relation to weight and glycemic control, with a greater impact on women. These results extend and corroborate previous observations, suggesting that gender per se may modulate the response to Liraglutide. Despite favorable effects on some established CVD risks factors, the long-term role of Liraglutide in primary prevention of CVD in patients with T2D remains controversial.

Suggested Citation

  • Maria Mirabelli & Eusebio Chiefari & Patrizia Caroleo & Biagio Arcidiacono & Domenica Maria Corigliano & Stefania Giuliano & Francesco Saverio Brunetti & Sinan Tanyolaç & Daniela Patrizia Foti & Luigi, 2019. "Long-Term Effectiveness of Liraglutide for Weight Management and Glycemic Control in Type 2 Diabetes," IJERPH, MDPI, vol. 17(1), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2019:i:1:p:207-:d:302583
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    References listed on IDEAS

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    1. Jessica E Potts & Laura J Gray & Emer M Brady & Kamlesh Khunti & Melanie J Davies & Danielle H Bodicoat, 2015. "The Effect of Glucagon-Like Peptide 1 Receptor Agonists on Weight Loss in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.
    2. Tanya M. Teslovich & Kiran Musunuru & Albert V. Smith & Andrew C. Edmondson & Ioannis M. Stylianou & Masahiro Koseki & James P. Pirruccello & Samuli Ripatti & Daniel I. Chasman & Cristen J. Willer & C, 2010. "Biological, clinical and population relevance of 95 loci for blood lipids," Nature, Nature, vol. 466(7307), pages 707-713, August.
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