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Restoration of p53 function leads to tumour regression in vivo

Author

Listed:
  • Andrea Ventura

    (Massachusetts Institute of Technology)

  • David G. Kirsch

    (Massachusetts Institute of Technology
    Massachusetts General Hospital)

  • Margaret E. McLaughlin

    (Massachusetts Institute of Technology)

  • David A. Tuveson

    (Massachusetts Institute of Technology)

  • Jan Grimm

    (Massachusetts General Hospital
    Harvard Medical School)

  • Laura Lintault

    (Massachusetts Institute of Technology)

  • Jamie Newman

    (Massachusetts Institute of Technology)

  • Elizabeth E. Reczek

    (Massachusetts Institute of Technology)

  • Ralph Weissleder

    (Massachusetts General Hospital
    Harvard Medical School)

  • Tyler Jacks

    (Massachusetts Institute of Technology
    Howard Hughes Medical Institute)

Abstract

p53 and tumour regression The p53 tumour suppressor is either mutated or inactivated by other alterations in most human cancers. Two papers in this issue show that even brief reactivation of the endogenous p53 genes in established tumours can cause cancer regression in some animal models. In some tumours, p53 reactivation causes cellular senescence associated with an innate immune response that contributes to tumour clearance. These experiments used gene manipulation to alter p53 levels, but they lend further support to the idea that p53-boosting drugs could be a useful form of cancer treatment.

Suggested Citation

  • Andrea Ventura & David G. Kirsch & Margaret E. McLaughlin & David A. Tuveson & Jan Grimm & Laura Lintault & Jamie Newman & Elizabeth E. Reczek & Ralph Weissleder & Tyler Jacks, 2007. "Restoration of p53 function leads to tumour regression in vivo," Nature, Nature, vol. 445(7128), pages 661-665, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7128:d:10.1038_nature05541
    DOI: 10.1038/nature05541
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    1. Luye An & Dahihm Kim & Leanne R. Donahue & Menansili Abraham Mejooli & Chi-Yong Eom & Nozomi Nishimura & Andrew C. White, 2024. "Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Kristoffer Sølvsten Burgdorf & Niels Grarup & Johanne Marie Justesen & Marie Neergaard Harder & Daniel Rinse Witte & Torben Jørgensen & Annelli Sandbæk & Torsten Lauritzen & Sten Madsbad & Torben Hans, 2011. "Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-6, January.
    3. Mariana Shumliakivska & Guillermo Luxán & Inga Hemmerling & Marina Scheller & Xue Li & Carsten Müller-Tidow & Bianca Schuhmacher & Zhengwu Sun & Andreas Dendorfer & Alisa Debes & Simone-Franziska Glas, 2024. "DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Wassim Abou-Jaoudé & Madalena Chaves & Jean-Luc Gouzé, 2011. "A Theoretical Exploration of Birhythmicity in the p53-Mdm2 Network," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-12, February.
    5. Claire Soudais & Romane Schaus & Camille Bachelet & Norbert Minet & Sara Mouasni & Cécile Garcin & Caique Lopes Souza & Pierre David & Clara Cousu & Hélène Asnagli & Andrew Parker & Paul Palmquist-Gom, 2024. "Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    6. Ignacio Bordeu & Lemonia Chatzeli & Benjamin D. Simons, 2023. "Inflationary theory of branching morphogenesis in the mouse salivary gland," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    7. Jonuelle Acosta & Qinglan Li & Nelson F. Freeburg & Nivitha Murali & Alexandra Indeglia & Grant P. Grothusen & Michelle Cicchini & Hung Mai & Amy C. Gladstein & Keren M. Adler & Katherine R. Doerig & , 2023. "p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    8. Natthakan Thongon & Feiyang Ma & Andrea Santoni & Matteo Marchesini & Elena Fiorini & Ashley Rose & Vera Adema & Irene Ganan-Gomez & Emma M. Groarke & Fernanda Gutierrez-Rodrigues & Shuaitong Chen & P, 2021. "Hematopoiesis under telomere attrition at the single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    9. C. Biben & T. S. Weber & K. S. Potts & J. Choi & D. C. Miles & A. Carmagnac & T. Sargeant & C. A. Graaf & K. A. Fennell & A. Farley & O. J. Stonehouse & M. A. Dawson & D. J. Hilton & S. H. Naik & S. T, 2023. "In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    10. Li Weng & Wen-Shuai Tang & Xu Wang & Yingyun Gong & Changqin Liu & Ni-Na Hong & Ying Tao & Kuang-Zheng Li & Shu-Ning Liu & Wanzi Jiang & Ying Li & Ke Yao & Li Chen & He Huang & Yu-Zheng Zhao & Ze-Ping, 2024. "Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    11. Samuel A Danziger & Roberta Baronio & Lydia Ho & Linda Hall & Kirsty Salmon & G Wesley Hatfield & Peter Kaiser & Richard H Lathrop, 2009. "Predicting Positive p53 Cancer Rescue Regions Using Most Informative Positive (MIP) Active Learning," PLOS Computational Biology, Public Library of Science, vol. 5(9), pages 1-12, September.
    12. L. Paige Ferguson & Jovylyn Gatchalian & Matthew L. McDermott & Mari Nakamura & Kendall Chambers & Nirakar Rajbhandari & Nikki K. Lytle & Sara Brin Rosenthal & Michael Hamilton & Sonia Albini & Martin, 2023. "Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    13. Christopher W. Murray & Jennifer J. Brady & Mingqi Han & Hongchen Cai & Min K. Tsai & Sarah E. Pierce & Ran Cheng & Janos Demeter & David M. Feldser & Peter K. Jackson & David B. Shackelford & Monte M, 2022. "LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    14. Jean-Philippe Coppé & Christopher K Patil & Francis Rodier & Yu Sun & Denise P Muñoz & Joshua Goldstein & Peter S Nelson & Pierre-Yves Desprez & Judith Campisi, 2008. "Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor," PLOS Biology, Public Library of Science, vol. 6(12), pages 1-1, December.
    15. Mei Zhao & Tianxiao Wang & Frederico O. Gleber-Netto & Zhen Chen & Daniel J. McGrail & Javier A. Gomez & Wutong Ju & Mayur A. Gadhikar & Wencai Ma & Li Shen & Qi Wang & Ximing Tang & Sen Pathak & Mari, 2024. "Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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